调胃舒颗粒剂对萎缩性胃炎大鼠血清一氧化氮含量的影响

Infl uence of Tiaoweishu Granules on Nitric Oxide Content in Serum of Rats with Atrophic Gastritis

目的观察调胃舒颗粒剂对萎缩性胃炎大鼠血清一氧化氮(NO)含量的影响。方法将SD大鼠随机分为正常对照组(A)、模型组(B)、调胃舒颗粒剂小剂量组(C)、调胃舒颗粒剂大剂量组(D)、三九胃泰治疗组(E),分别处理后观察大鼠体质量改变等一般情况,并测定血清NO含量。结果 C组与D组血清NO含量均显著高于B组与E组(P<0.05);D组显著高于C组(P<0.05)。D组大鼠体质量上升情况显著优于B组、C组、E组。结论调胃舒颗粒剂对萎缩性胃炎大鼠有治疗作用;对血清NO的影响呈量-效关系。

Objective： To explore Nitric oxide （NO） levets in serum of rats with atrophic gastritis treated by Tiaoweishu Granules. Methods： SD rats were randomly divided into five groups which were normal control group, atrophic gastritis model group,Tiaoweishu granules low-dose group, Tiaoweishu Granules high-dose group, and Sanjiuweitai treatment group. Change of weight was observed after treatment and contents of NO in serum were determined. Groups were compared after statistics processing. Results ： Content of NO in serum of high-dose group and low-dose group were significantly higher than those of model group and Sanjiuweitai treatment group （P〈 0.05）. Content of NO in serum of high-dose group was significantly higher than that of low-dose group （P〈 0.05）. Rats putting more weight in high-dose group than ranitidine model group,low-dose group,and control group. Conclusion： Tiaoweishu Granules has a therapeutic effect on rats with atrophic gastritis and certain influ- ence on NO in serum. Different dosage of Tiaoweishu granules has different effects on NO in serum. This could be one of the mechanisms of Tiaoweishu granules treating atrophic gastritis.