百裕银杏内酯注射液抑制家兔血小板聚集作用的实验研究被引量：22

The Effects of Bai Yu ginkgolide Injection on Platelet aggregation in rabbits

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摘要目的观察不同低剂量的百裕银杏内酯注射液对家兔血小板聚集功能、超微结构及PF-4和β-TG的影响。方法将日本大耳兔分为百裕银杏内酯高、中、低剂量组及生理盐水组,分别予相应药物静注1周,采用体内实验法,观察各组对血小板活化因子(PAF)诱导的家兔血小板聚集作用的影响,以及血小板超微结构和PF-4和β-TG水平的变化。结果百裕银杏内酯各剂量组较生理盐水组均能抑制PAF诱导的家兔血小板聚集,减少聚集型血小板数量并使树突型血小板突起变少变短,降低PF-4和β-TG的表达(P<0.01)。结论百裕银杏内酯注射液能够抑制PAF诱导的血小板聚集,抑制血小板的活化。 Aim： To observe the effects of Bai Yu ginkgolide injection on platelet aggregation, ultra structure and PF-4 and β-TG level in rabbits. Methods： Japanese big ear rabbits were randomly divided into Bai Yu ginkgolide Injection Low dose group, middle dose group, high dose group, and saline group, all of which were given corresponding treatment. In vivo experiments, when PAF induced platelet aggregation, platelet aggregation, ultra structure and PF-4 and β-TG level were observed. Results： Bai Yu ginkgolide injection could inhibit plate ag- gregation, reduce the number of aggregation type platelets and make fewer and shorter processes of dendritic platelets and reduce the level of PF-4 and β-TG significantly （P〈 0.01 ）. Conclusion： Bai Yu ginkgolide injec- tion could antagonism PAF-induced platelet aggregation, inhibit the activation of platelets, and is a kind of im- portant anti platelet aggregation drug.

作者徐露黄彦

机构地区重庆医科大学生化与分子药理学重点实验室重庆市中医院

出处《中国中医急症》 2014年第4期638-639,643,共3页 Journal of Emergency in Traditional Chinese Medicine

基金重庆市中医院院内培育课题(2012-1-2-17)

关键词百裕银杏内酯注射液血小板血小板活化因子电镜 Bai Yu Ginkgolide Injection Platelet PAF Electron Microscopy

分类号 R971.1 [医药卫生—药品]

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