软肝丸治疗血吸虫病肝纤维化的效果

Curative effect of Ruangan pills in treatment of schistosomiasis liver fibrosis

目的探讨水飞蓟宾联合软肝丸治疗血吸虫病肝纤维化的疗效、机制及安全性。方法将200例血吸虫病肝纤维化患者随机分为对照组和治疗组,每组100例,分别采用水飞蓟宾(对照组)、水飞蓟宾联合软肝丸口服(治疗组),于治疗3、6、9个月和12个月,比较观察2组患者的临床效果。结果治疗12个月后,患者5项临床症状治疗组明显减轻,总有效率均达75%以上,均显著高于对照组。肝脏B超分级治疗组与对照组比较,3、6个月时无改善(P均>0.05),9、12个月时,治疗组好于对照组(P均<0.05)。治疗组治疗3、6个月时均无改善(P均>0.05),9、12个月时较6个月时有改善(P均<0.05)。血清肝纤维化四项,治疗3个月时,治疗组与对照组差异无统计学意义(P>0.05);6、9、12个月时,差异均有统计学意义(P均<0.05);治疗组治疗3、6个月时比较,差异无统计学意义(P>0.05),9、12个月时均低于6个月时(P均<0.05)。治疗过程中未出现明显不良反应。结论水飞蓟宾联合软肝丸有较好的抗血吸虫病肝纤维化的作用。

Objective To explore the efficacy,mechanism and safety of silibinin combined with Ruangan pills（a Chinese herbal preparation）in the treatment of schistosomiasis liver fibrosis. Methods A total of 200 patients with schistosomiasis liver fibrosis were randomly divided into a control group and a treatment group,and 100 patients in each group were respectively admin-istered with oral silibinin alone and oral silibinin combined with Ruangan pills,respectively. The curative effects in the two groups were evaluated in 3 months,6 months,9 months and 12 months respectively. Results The common five clinical symptoms of schistosomiasis liver fibrosis patients significantly relieved in the treatment group 12 months after the therapy,and the total effi-ciency reached more than 75%,which were significantly higher than that in the control group. In the treatment group and the con-trol group,there was no improvement in the liver B ultrasonic classification 3 months and 6 months after the therapy（P＆gt;0.05）;however,in 9 months and 12 months,the liver B ultrasonic classification in the treatment group was better than that in the control group（P＆lt;0.05,P＆lt;0.01,respectively）. For the four serum indexes of liver fibrosis,there was no significant differences between the two groups in 3 months,however,in 6 months,9 months,and 12 months,there was a significant improvement in the treat-ment group compared with the control group. There were no obviously adverse effects in two groups. Conclusion Silibinin com-bined with Ruangan pills has a better curative effect in the treatment of schistosomiasis liver fibrosis.