摘要
目的:探讨熊果酸对大鼠体内瑞舒伐他汀的药代动力学影响。方法12只雄性 SD 大鼠(200~235 g)按随机数字表法分为2组,分别为单用瑞舒伐他汀组与瑞舒伐他汀合用熊果酸组,每组6只,以瑞舒伐他汀100 mg· kg^-1、熊果酸80 mg·kg^-1的剂量灌胃给药,两药合用时先熊果酸后瑞舒伐他汀相继灌胃。采用 LC-MS 测定血药浓度,比较2组间药代动力学参数。结果合用熊果酸后,瑞舒伐他汀药代动力学参数 Cmax、AUC0-t、AUC0-∞参数值分别增加163.02%、145.99%和157.55%,而 CLz/F 值降低了57.84%(P <0.05或 P <0.01)。结论熊果酸可影响大鼠体内瑞舒伐他汀的药代动力学特性。
Objective To study the effect of ursolic acid on the pharmacokinetics of rosuvasta-tin in rats.Methods Twelve male rats(200-235 g)were randomly given rosuvastatin alone(control group)or in combination with ursolic acid(treatment group),with 6 rats in each group.Rosuvastatin(100 mg·kg^-1 ),ursolic acid(80 mg·kg^-1 )were adiministered by intragastric adminis-tration.Combination of both recipes were adiministered first ursolic acid.LC-MS was used to determine the plasma concentrations of rosuvastatin.Pharmacokinetic parameters were compared between the two groups.Results Compared with control group,Cmax ,AUC0-t and AUC0-∞ parameters were respectively increased by 163.02%,145.99% and 157.55%,but CLz/F was decreased by 57.84% in treatment group(P 〈0.05 or P〈0.01).Conclusion Ursolic acid can affect the pharmacokinetic properties of rosuvastatin in rats.
出处
《南昌大学学报(医学版)》
CAS
2014年第2期1-4,共4页
Journal of Nanchang University:Medical Sciences
基金
国家自然科学基金青年项目(81202583)
江西省教育厅青年基金(GJJ12145)