氯吡格雷联合阿司匹林在急性轻度脑梗死治疗中的应用

Application of Clopidogrel Combined with Aspirin in Treatment of Acute Mild Cerebral Infarction

目的探讨氯吡格雷联合阿司匹林治疗急性轻度脑梗死的有效性和安全性。方法 2011年9月—2012年9月发病72 h内入院的符合标准的急性轻度脑梗死356例,随机分为阿司匹林+氯吡格雷组(双抗组)和阿司匹林组(单抗组),每组178例。双抗组给予氯吡格雷联合阿司匹林,单抗组给予阿司匹林,两组疗程均为14 d。观察两组病情进展情况、入院时及治疗后神经功能缺损评分量表(NIHSS)评分及不良反应发生情况。结果双抗组病情进展率低于单抗组(P<0.05)。NIHSS评分两组入院时和治疗后比较差异均无统计学意义(P>0.05),但治疗后两组均低于入院时(P<0.05)。两组均未出现严重不良反应。结论氯吡格雷联合阿司匹林治疗急性轻度脑梗死可有效阻止卒中进展,改善预后,且安全性较好。

Objective To investigate the curative effect and safety of Clopidogrel combined with Aspirin in treat- ment of acute mild cerebral infarction. Methods A total of 356 patients with acute mild cerebral infarction within 72 h invasion during September 2011 and Septembers 2012 were randomly divided into Aspirin and Clopidogrel group （group A, n = 178） and Aspirin group （group B, n = 178）. The course of treatment of each group was 14 d. Progressions of pathogenetic condition, scores of national institute of health stroke scale （NIHSS） upon admission and after treatment, and incidence rate of adverse reactions in the two groups were observed. Results Aggravation rate of the group A was lower than that of the group B （ P 〈 0. 05 ）. There were no significant differences between the two groups in NINSS scores at admission and after treatment （ P 〉 0.05 ）, but the score after treatment in each group was lower than that upon admis- sion （P 〈 0.05）. There was no severe adverse reaction. Conclusion Clopidogrel combined with Aspirin in treatment of acute mild cerebral infarction may effectively reduce aggravation rate and improve the prognosis with good safety.