激活腺苷酸活化蛋白激酶天然产物对脂代谢调节作用研究进展

Actions of natural products in regulating lipid metabolism through activating AMP-activated protein kinase: research advances

腺苷酸活化蛋白激酶(AMPK)是一种广泛参与调节细胞代谢的激酶,被称为"能量感受器"。当胞浆中AMP/ATP比例升高,或其他因素激活AMPK时,AMPK可促进脂肪酸氧化,增加能量产生;同时还可以抑制脂质合成等代谢通路,减少能量消耗,从而使细胞能量代谢保持平衡。自然界的植物中存在许多具有调节脂质代谢作用的天然产物,如黄酮类、皂苷类、生物碱类和萜类等,它们调节脂质代谢的作用机制各不相同。近年来,发现了很多天然产物具有通过激活AMPK调节脂质代谢的作用,本文将对这些天然产物研究进展进行总结。

AMP-activated protein kinase （AMPK） is an energy sensor playing a key role in regulation of cellular metabolism. When activated by increased intracellular AMP/ATP ratio or by other factors, AMPK promotes the oxidation of fatty acid, increases en- ergy production and improves glucose uptake and use. Meanwhile, it inhibits glycogen synthesis, gluconeogenesis and lipid synthesis, thus reducing energy consumption and keeping the balance of cell energy metabolism. There are many natural products with regulating lipid metabolism such as flavones, saponins, and alkaloids. Their mechanisms of regulating lipid metabolism are different. In recent years, many natural products with AMPK-activating activity have been identified. This paper reviews the research progress in the actions of natural products in regulating lipid metabolism through activation of AMPK.