血清神经元特异性烯醇化酶与脑电图对手足口病合并脑炎患儿的临床应用价值

Clinical Value of Electroencephalogram and Serum Level of Neuron-Specific Enolase on Hand-Foot-Mouth Disease Complicated with Encephalitis

目的:探讨血清神经元特异性烯醇化酶(NSE)水平与脑电图(EEG)检查在手足口病(HFMD)合并脑炎患儿中的临床应用价值。方法:分析2010年1月至2012年12月我院收治的68例确诊为HFMD合并脑炎患儿的临床资料、EEG及血清NSE水平,并分析HFMD合并脑炎患儿的脑炎严重程度与EEG异常程度及血清NSE水平之间的关系。结果:68例HFMD合并脑炎患儿的首次EEG检查异常率为100%,HFMD合并脑炎患儿的脑炎严重程度与EEG的异常程度呈显著正相关(rs=0.4397,P<0.01)。重度脑炎组血清NSE含量为(14.31±2.46)μg/L,明显高于中度组的(12.28±1.96)μg/L及轻度组的(10.31±1.22)μg/L(q=8.367及8.072,P均<0.01)。结论:EEG及血清NSE水平对HFMD并发脑炎的严重程度判断具有重要价值。

Objective： To study the clinical value of electroencephalogram （EEG） and serum levels of neuron-specific enolase on hand-foot-mouth disease （HFMD） complicated with encephalitis. Methods： The clinical data, EEG and serum levels of neuron-specific enolase（NSE） among sixty-eight cases of HFMD complicated with encephalitis were analyzed from January 2010 to December 2012. Relationship between abnormal degree of their EEG and serum levels of neuron-specific enolase and severity of HFMD complicated with encephalitis were observed. Results： The EEG abnormality rate in sixty-eight cases of HFMD complicated with encephalitis was 100%. Clinical grading of HFMD complicated with encephalitis and the levels of EEG abnormality were significantly correlated （ r, = 0. 4397, P〈0.01）. Serum levels of NSE in the severe encephalitis group [ （14.31 ±2.46） μg/L] were significantly higher than that in the moderate encephalitis group [ （12.28±1.96） μg/L] and the mild encephalitis group [ （10.31±1.22） μg/L] （SNK-q=8. 367, 8. 072, P〈0. O1 ）. Conclusions： EEG and serum levels of NSE can be considered as the valuable indicator to evaluate the severity of HFMD complicated with encephalitis.