不同剂量氨茶碱用于小儿哮喘的疗效及安全性对比

Curative Effect and Safety of Different Doses of Aminophylline in the Treatment of Asthma in Children

目的:探讨不同剂量氨茶碱在小儿哮喘治疗中的临床疗效。方法:选择2008年5月-2012年5月因哮喘发作入住笔者所在医院治疗患儿222例,按计划分为两组,每组111例,分别给予分次氧驱动雾化吸入氨茶碱法(观察组)和单次静滴氨茶碱法(对照组),比较两组患儿治疗后症状消失时间、临床效果和不良反应发生情况。结果:观察组气促消失时间(0.67±0.29)d明显少于对照组的(0.98±0.21)d,喘憋消失时间(1.05±0.31)d明显少于对照组的(1.87±0.47)d,显效率80.2%明显高于对照组55.9%,总不良反应发生率0.9%显著低于对照组的12.6%。结论:分次氧驱动雾化吸入氨茶碱在小儿毛细支气管炎治疗中症状消失快,临床效果好,不良反应发生率低,适合临床广泛应用。

Objective： To investigate the clinical effect of different doses of Aminophylline in the treatment of asthma in children.Method： Selecting 222 children with asthma from May 2008 to May 2012 in our hospital, according to the plan, they were divided into two groups, 111 cases in each group, observation group was given oxygen atomizing inhalation of Aminophylline method, and control group was treated with a single intravenous Aminophylline method, the symptoms disappeared time, clinical effect and adverse effect of two groups were compared.Result： In the observation group, shortness of breath disappear time was （0.67± 0.29）d, was significantly less than that of control group （0.98 ± 0.21）d.The wheezing disappearance time（1.05 ± 0.31）d was obviously less than that of control group（1.87 ±0.47）d.The effective rate of the observation group（80.2%） was significantly higher than that of control group（55.9%）, the total adverse reaction rate of the observation group（0.9%） was significantly lower than that of control group（12.6%）.Conclusion： Fractional oxygen atomizing inhalation of Aminophylline in the treatment of infantile brenchiolitis clinical symptoms disappeares quickly, has good effect and low incidence of adverse reactions, is suitable for wide clinical application.