缺血性脑卒中患者住院死亡危险因素分析

Analysis of risk factors for hospitalized death in ischemic stroke patients

目的探讨缺血性脑卒中患者住院死亡的危险因素。方法收集2011年1月至2012年12月我院神经内科住院确诊的1275例急性缺血性脑卒中病例，采用统一设计的调查表，调查内容包括个人特征、既往史、实验室检查结果、临床特征等．对影响卒中死亡的相关因素进行单因素及多因素分析。结果1275例患者住院期间死亡25例．病死率为2．0％。经单因素及多因素回归分析显示，与卒中死亡相关的因素为年龄（OR=4．435，95％CI：1．245～15．798）、白细胞计数（OR：3．974。95％CI：1．620。9．748）、入院美国国立卫生院卒中量表（National Institutes of Health Stroke Scale．NIHSS）评分（OR=2A88，95％CI：1．665～3．717）及并发症（08：4．021，95％CI：1．608-10．052）。结论鬲龄、自细胞计数高、人院NIHSS评分高及有并发症是缺血性脑卒中患者住院死亡的重要危险因素。

Objective To investigate the risk factors for hospitalized death of ischemie stroke patients. Methods One thousand two hundred and seventy-five cases of acute ischemic stroke admitted into our hospital between January 2011 and December 2012 were retrospectively collected. A uniform designed questionnaire was used to investigate the possible associated risk factors. The survey contents included personal characteristics, past medical history, clinical laboratory results and clinical features. The influential risk factors on fatality were analyzed by monovariable analysis and muhivariable analysis. Results Twenty-five cases died during hospitalization. The mortality rate was 2.0%. Monovariant and multivariant regression analysis showed that the factors associated with death were age （OR=4.435, 95%Ch 1.245-15.798）, leukocyte count （OR=3.974, 95%CI：1.620-9.748）, admission NIHSS score （OR=2.488, 95%CI：1.665- 3.717） and complications （OR=4.021, 95%CI：1.608-10.052）. Conclusion Old age, high leukocyte count, high admission NIHSS score and concurrent complications are the important risk factors associated with hospitalized death in ischemic stroke patients.