奥美拉唑不同疗程治疗胃食管反流病的疗效观察

Efficacy Observation of Different Courses of Omeprazole in the Treatment of Gastroesophageal Reflux Disease

目的:观察奥美拉唑不同疗程治疗胃食管反流病(GERD)的疗效和安全性。方法:选择80例GERD患者,所有患者均口服奥美拉唑20 mg,bid,分别于治疗4周、6周时观察患者的临床疗效,比较治疗前、治疗4周、6周时的反酸、烧心的症状积分,并于治疗6周时复查胃镜。结果:治疗4周、6周后,患者的反酸、烧心等症状明显减轻,症状积分均较治疗前显著下降,且治疗6周时显著优于治疗4周时,差异有统计学意义(P<0.05);治疗6周时的总有效率(95.0%)显著高于治疗4周时(70.0%),差异有统计学意义(P<0.05)。经胃镜检查,治疗6周时的胃镜积分改善情况显著优于治疗4周和治疗前,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义。结论:奥美拉唑治疗GERD疗效与安全性均较好,且治疗6周的疗效优于治疗4周。

OBJECTIVE： To observe therapeutic efficacy and safety of different courses of omeprazole in the treatment of gas troesophageal reflux disease. METHODS： 80 cases of gastroesophageal reflux disease admitted were selected and given omeprazole 20 mg, bid, orally. The symptoms of acid reflux and heartburn were observed after 4 weeks and 6 weeks of treatment, and gastroscopy was carried out again 6 weeks after treatment. RESULTS： At 4th and 6th week, the symptom of acid reflux and heartburn were relieved significantly, and the symptom score decreased significantly, compared with before treatment therapeutic efficacy of 6 weeks of treatment is significantly better than 4 Weeks of treatment; there was statistical significance （P〈0.05）. At 6th week, the effective rate was 95.0%, which was significantly higher than 4th week （70.0%）; there was statistical significance （P〈0.05）. After gastroscopy, total effective rate of symptom improvement at 6th week was higher than 4 weeks of treatment; there was statis- tical significance（P〈0.05）. The incidence rate of ADR had no statistical significance between 2 groups. CONCLUSIONS： Omepra- zole is effective and safe in the treatment of reflux esophagitis; therapeutic efficacy of 6 weeks of treatment is significantly better than 4 weeks of treatment.