摘要
目的研究甲硝唑在家兔胆汁中的浓度动态分布，为预防和治疗肝胆系统厌氧菌感染提供参考和依据。方法家兔行胆总管造瘘术，静脉注射甲硝唑后于不同时间点采集胆汁标本，采用高效液相色谱法（HPLC）测定其在胆汁中的浓度，了解用药后不同时间药物在胆汁中的动态分布。结果家兔静脉注射甲硝唑（40mg／kg）后0．25h胆药浓度即大大超过有效杀菌浓度，胆汁药物达峰时间Tmax为（0．29±0．10）h；峰浓度Cmax为（29．49±10．02）±g／mL，远远超过其对厌氧菌的有效杀菌浓度（0．25-2μg／mL），给药后4h胆药浓度仍达到最低抑菌浓度。结论甲硝唑可作为预防和治疗胆道厌氧菌感染较好的药物。
Objective To study the concentration and dynamic distribution of metronidazole in rabbit bile. Methods After anaesthesia, the common bile duct of rabbit was isolated and cannulated with a silicone tube. The rabbits were administered intravenously with the dose of 40mg/kg of metronidazole. Bile（1.SmL） was collected at different time points after administration, and concentration of the antibiotic in bile was assayed by HPLC. The bile drug concentration-time data were gained. Results After a single i.v. administration of 40mg/kg of metronidazole in each rabbit, drug concentrations reached Cmax （29.49±10.02） μg/mL immediately in bile, which had largely exceeded the minimum inhibition concentrations （MIC） for most anaerobic organisms ranging from 0.25 to 2μg/mL. Then the bile concentration of metronidzole decreased with time. But even after 4 hours of the intravenous infusion, metronidazole was still to remain over the MIC. Conclusions Metronidazole could be recommended as a practical and promising antianaerobic drug for the treatment ofbiliary tract infection.
出处
《国外医药（抗生素分册）》
CAS
2014年第3期128-130,133,共4页
World Notes on Antibiotics
