P-选择素、高敏C反应蛋白与急性冠状动脉综合征发病的相关性研究

Clinical study of P-selectin, Hs-CRP and acute coronary syndrome

目的探讨P-选择素、高敏C反应蛋白(Hs-CRP)与急性冠状动脉综合征(ACS)发病的相关性。方法采用酶联免疫法测定42例ACS患者、27例稳定型心绞痛(SAP)患者及29例非冠心病患者(对照组)的P-选择素、Hs-CRP的血清学水平并进行组间比较,用Logistic回归分析法分析P-选择素、Hs-CRP水平和已知冠心病危险因素对ACS发病的影响。结果 ACS组P-选择素、Hs-CRP水平明显高于稳定型心绞痛组和对照组(P<0.01),心肌梗死组P-选择素、Hs-CRP水平明显高于不稳定心绞痛组(P<0.01)。多元Logistic回归分析发现P-选择素(OR=1.652)、Hs-CRP(OR=2.420)是ACS的影响因素。结论血清P-选择素、HsCRP水平的升高与ACS的发生密切相关,可作为判断ACS患者粥样斑块是否稳定以及观察病情变化的血清学指标之一。

[Objective] To analyze the relationship between PS, Hs-CRP with acute coronary syndrome. [Methods] The concentrations of plasma soluble PS and Hs-CRP were measured by enzyme linked immu- osorbent assay （ELLISA） in 42 patients with ACS and 27 patients with SAP and 29 normal persons. The relationship between PS, Hs-CRP with ACS related risk factors were analyzed by Logistic regression analysis. [Results] The one way ANOVA statistical analysis manifested ACS groups＇ PS and Hs-CRP levels were significantly higher than control group and SAP group （All P〈0.01）, moreover, MI group were obviously higher than UAP group （P〈0.01）. Multivariate logistic regression analysis showed that PS and Hs-CRP levels were the significant variables for ACS. [Conclusion] The levels of serum PS and Hs-CRP are closely related to the occurrence of ACS, can be used as serological indexes detect the condition changes of ACS.