普瑞巴林与阿米替林治疗带状疱疹后遗神经痛的疗效和安全性观察被引量：1

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摘要目的探讨普瑞巴林与阿米替林治疗带状疱疹后遗神经痛疗效和安全性。方法将54例带状疱疹后遗神经痛患者随机分为两组,每组各27例,治疗组予以口服普瑞巴林治疗,对照组予以口服阿米替林治疗。比较两组患者治疗前后视觉模拟评分(VAS)、睡眠评分、镇痛有效率和不良反应发生率的差异。结果两组患者治疗后各时间点VAS评分及睡眠评分较治疗前均明显下降(P<0.05),与对照组比较,治疗组患者治疗后2、4、6周VAS评分、睡眠评分降低更明显,差异有统计学意义(P<0.05)。治疗组镇痛有效率明显高于对照组(P<0.05),二者不良反应发生率差异无统计学意义。结论普瑞巴林与阿米替林比较,能更快、持久地缓解PHN,不良反应轻且呈一过性,患者耐受性较好。

作者王鹏唐岚江惟苏刘付华

机构地区清远市人民医院皮肤科清远市人民医院感染科

出处《中国医药指南》 2014年第13期100-101,共2页 Guide of China Medicine

关键词普瑞巴林阿米替林带状疱疹后遗神经痛

分类号 R752.12 [医药卫生—皮肤病学与性病学]

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