慢性阻塞性肺病急性加重期患者血浆D-二聚体的临床意义和CRP的相关性

Chronic Obstructive Pulmonary Disease Acute Exacerbation Patients with Clinical Significance of Plasma D-dimer and CRP Correlation

目的探讨慢性阻塞性肺病急性加重期(AECOPD)患者D-二聚体的变化及其与CRP的相关性。方法选择慢性阻塞性肺病急性期患者38例及其经治疗稳定期患者31例和正常对照组患者,测定血浆D-二聚体及CRP含量,研究其变化,并对CRP与血浆D-二聚体水平的相关性进行分析。结果 AECOPD患者治疗前血浆D-二聚体、CRP水平明显高于COPD稳定期及正常对照组,COPD稳定期血浆D-二聚体、CRP水平高于正常对照组,患者的CRP与血浆D-二聚体呈正相关的关系。结论血浆中的D-二聚体可作为反映AECOPD患者病情的理想指标,对治疗效果的判断有重要的价值。

Objective To investigate the acute exacerbation of chronic obstructive pulmonary disease （AECOPD） in patients with D-dimer changes and its correlation with CRP. Methods Choose 38 patients with acute phase of chronic obstructive pulmonary disease and the treatment of patients with 31 patients with stability and normal control group, plasma D-dimer and CRP levels to study its changes, and plasma D-dimer levels of CRP and the correlation analysis. Results AECOPD patients plasma D-dimer and CRP levels before treatment was significantly higher stability and normal control group, COPD stabilization of plasma D-dimer, CRP levels higher than the normal control group, patients with CRP was positively correlated with plasma D-dimer. Conclusion Plasma D-dimer can be used as an ideal index to reflect the AECOPD of the patient＇s condition, have important value to judge the curative effect.