摘要
通过急性毒性试验、亚慢性毒性试验、沙门氏菌/回复突变试验、细胞微核试验、口腔黏膜影响试验和牙龈黏膜影响试验等,对救必应提取物在牙膏中使用的安全性进行了评价。结果表明,救必应提取物属于实际无毒级物质,无基因突变和染色体畸变的危险,对口腔黏膜和牙龈黏膜无刺激,可安全应用于牙膏等口腔护理产品之中。
For evaluating the safety of the extract of Ovateleaf Holly Bark that adopted in toothpaste, the acute toxicity test, sub -chronic toxicity test, salmonella typhimurium/reverse mutation assay, mammalian erythrocyte micronucleus test, oral mucosa impact test and gingival mucosa impact test were conducted. Test results showed that the extract of Ovateleaf Holly Bark belongs to practically non - toxic grade material, and there is no danger of gene mutation and chromosome aberration, no stimulation to mouth mucosa and gingiva. So it can be safely applied to oral care product.
出处
《日用化学工业》
CAS
CSCD
北大核心
2014年第5期278-281,284,共5页
China Surfactant Detergent & Cosmetics
关键词
牙膏
救必应
安全性评价
toothpaste
Ovateleaf Holly Bark
safety evaluation