阿立哌唑预防女性分裂症患者抗精神病药所致高泌乳素血症的研究

The Study of Aripiprazole on preventing the hyperprolactinemia induced by antipsychotics on female schizophrenic patients

目的探讨阿立哌唑预防女性分裂症患者抗精神病药所致高泌乳素血症的作用。方法对100例女性精神分裂症患者随机分为两组,各50例,研究组给予利培酮及小剂量的阿立哌唑联合治疗,对照组单用利培酮治疗,观察6月,治疗前和治疗后第1、3、6月末分别予以阳性和阴性综合症状量表(PANSS)、临床疗效总评量表(CGI)和治疗中出现的症状量表(TESS)评定病情的严重程度、疗效和不良反应,并完善实验室检查。结果①两组患者治疗后的总有效率类似(92%与90%),差异无统计学意义;PANSS及CGI总分均低于治疗前,差异有统计学意义,但两组间差异无统计学意义;②研究第1月末,两组药物副反应主要表现为锥体外系症状,TESS评分两组之间差异无统计学意义;研究结束时对照组TESS的严重程度及痛苦感觉的评分均要高于研究组,差异有显著统计学意义。药物副作用主要表现为月经紊乱、闭经、溢乳等高泌乳素血症综合征症状;③研究结束时,两组患者血清泌乳素水平差异有显著统计学意义,对照组明显高于研究组。结论小剂量的阿立哌唑可以减少发生女性分裂症患者抗精神病药所致的高泌乳素血症。

Objective Objective To approach the effects of aripiprazole on preventing the hyperprolactinemia induced by antipsychotics on female schizophrenic patients. Methods 100 female schizophrenic patients were randomly divided into two groups receiving risperidone for 6 mouths, the study group were given low dose aripiprazole at the same time. The clinical effect and side effect were evaluated by the positive and negative syndrome scale （ PANSS）, Clinical Global Impression （CGI） and the treatment emergent symptom scale （TESS） before and 1, 3, 6 months after the treatment. At the same time we undertook the plasma prolactin examination. Result ①At the end of the study, there were no differences between the two groups in the efficacy to psychiatric symptoms; the score of PANSS and CGI were decreased obviously, but there were no differences between the two groups; ②The main side effect were extrapyramidal symptoms in the two groups at the first month, there were no differences in the TESS score between the two groups; but at the sixth month, The severity and pain feeling of TESS were higher in the control group than that in the study, the differences were significant between the two groups, the symptoms of hyperprolactinemia were such as menstrual disorder, amenorrhea and galactorrhea; ③At the end of the study, the plasma prolactin level of control group was higher than that of the study, there were significant differences between the two groups. Conclusion Low dosage aripiprazole can prevent the from antipsychotics on female schizophrenia patients.