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甲状旁腺激素制剂治疗代谢性骨病

Parathyroid hormone in the treatment of metabolic bone diseases
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摘要 甲状旁腺激素（PTH）是调节钙平衡及骨转换的重要内分泌激素.目前已有PTH氨基端1-34片段和PTH 1-84全段两种重组甲状旁腺激素,用于治疗严重原发性及糖皮质激素诱发性骨质疏松.最近研究发现,PTH制剂对甲状旁腺功能减退症、成骨不全症、低磷酸酶症等代谢性骨病也有良好疗效. Parathyroid hormone （PTH） is an important hormone in maintaining calcium balance and modulating bone remodeling. Now there are two forms of recombinant PTH （PTH 1-34 and PTH 1-84） in the treatment of severe primary osteoporosis and glucocorticoid induced osteoporosis. Recently,PTH has been found to be effective in other metabolic bone diseases, such as hypoparathyroidism, osteogenesis imperfecta and hypophosphatasia.
作者 吕芳 李梅
机构地区 中国医学科学院
出处 《国际内分泌代谢杂志》 北大核心 2014年第3期180-183,共4页 International Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目（81100623） 国家临床重点专科课题（WBYZ 2011-873）
关键词 甲状旁腺激素制剂 代谢性骨病 治疗 Parathyroid hormone Metabolic bone diseases Treatment
分类号 R68 [医药卫生—骨科学]
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参考文献27

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国际内分泌代谢杂志
2014年 第3期

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