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右美托咪定预防喉切除患者苏醒期躁动20例 被引量:5

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摘要 目的探讨右美托咪定对喉切除患者苏醒期躁动的预防效果。方法择期行全喉切除患者40例,随机分为治疗组和对照组各20例。选择静吸复合全身麻醉,手术结束前30 min,治疗组给予右美托咪定0.4μg·kg-1,稀释至50 mL,静脉滴注,15 min注完。对照组静脉滴注等量0.9%氯化钠注射液50 mL,15 min注完。术毕送入恢复室。监测记录右旋美托咪啶注射前(t0),注射后(t1),手术结束时(t2),清醒时(t3)的心率(HR)、平均动脉压(MAP)。记录麻醉时间、手术时间、停药至清醒时间。观察患者手术后躁动的发生情况。结果对照组t3时间点HR、MAP值比t0、t1、t2明显升高(P<0.05)。治疗组各时间点较t0无明显变化;治疗组和对照组躁动发生率分别为5.0%,30.0%(P<0.01)。结论右美托咪定显著减少喉切除患者苏醒期躁动。
出处 《医药导报》 CAS 北大核心 2014年第5期612-613,共2页 Herald of Medicine
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