脱氧雪腐镰刀菌烯醇吸附剂对断奶仔猪生长性能、血清生化指标及肠道形态的影响

Effects of Deoxynivalenol Adsorbent on Growth Performance,Serum Biochemical Indexes and Intestinal Morphology of Weaner Piglets

本试验旨在研究脱氧雪腐镰刀菌烯醇（ deoxynivalenol，DON）污染饲粮中添加DON吸附剂对断奶仔猪生长性能、血清生化指标及肠道形态的影响。选取120头（36±4）日龄断奶仔猪，随机分为3组（每组4个重复，每个重复10头猪），分别为阴性对照（ NC）组、DON组（阳性对照）、DON＋吸附剂（ DON＋AD）组，试验期28 d。结果表明：1）试验1～14 d，DON组较NC组平均日增重（ADG）下降21.24％（P＜0.05），料重比（F/G）上升15.15％（P＜0.05）；DON＋AD组较DON组ADG提高17.11％（P＜0.05），F/G下降10.53％（P＜0.05）。试验15～28 d及试验全期各组间ADG和平均日采食量均无显著差异（P＞0.05）。2） DON组较NC组血清总蛋白含量显著下降（P＜0.05），葡萄糖含量显著上升（P＜0.05），DON＋AD组较NC组血清葡萄糖、尿素氮含量显著下降（P＜0.05）。3） DON组较NC组血清肌酸激酶、谷丙转氨酶活性显著提高（P＜0.05），而加入吸附剂后血清肌酸激酶、谷丙转氨酶、谷草转氨酶活性则恢复到正常水平。4） DON组较NC组空肠绒毛高度和绒毛高度/隐窝深度分别下降21.18％和17.97％（P＜0.05）， DON＋AD组较DON组空肠绒毛高度增加16.49％（ P＜0.05）。因此，DON污染饲粮降低了试验1～14 d断奶仔猪的生长性能，添加DON吸附剂能够改善DON对断奶仔猪生长性能的不利影响，并缓解DON对断奶仔猪所产生的肠道损伤。

This study was conducted to investigate the effects of deoxynivalenol （ DON） adsorbent on growth performance, serum biochemical indexes and intestinal morphology of weaner piglets fed DON-contaminated diets.One hundred and twenty weaner piglets at （36±4） days of age were randomly allocated to 3 groups （4 replicates per group and 10 piglets per replicate）： negative control （ NC） group, DON group （ positive control） and DON＋adsorbent （ DON＋AD） group.The trial lasted for 28 days.Results showed as follows：1） on 1 to 14 days of experiment, compared with NC group, average daily gain （ ADG） in DON group was reduced by 21.24%（ P〈0.05） and feed/gain （ F/G） was increased by 15.15%（ P〈0.05） .ADG in DON＋AD group was higher by 17.11%than that in DON group （ P〈0.05） and F/G was lower by 10.53%than that in DON group （ P〈0.05） .On 15 to 28 days of experiment and during the whole trial period, ADG and average daily feed intake were no significant differences among all groups （ P〈0.05） .2） Compared with NC group, the serum total protein content in DON group was significantly decreased （ P〈0.05） and glucose content was significantly increased （ P〈0.05） .In DON＋AD group, serum glucose and urea nitrogen contents were significantly decreased compared with NC group （ P〈0.05） .3） Compared with NC group, the serum activities of creatine kinase （CK） and glutamic-pyruvic transaminase （GPT） were significantly increased （P〈0.05）, while after adding the adsorbent, the serum activities of CK, GPT and glutamic-oxal（ o） acetic transaminase （ GOT） were returned to normal level.4） Compared with NC group, the villous height and villous height/crypt depth of jejunum in DON group were decreased by 21.18%and 17.97%（ P〈0.05） , respectively, and DON＋AD group had a 16.49%higher jejunum villous height than DON group （P〈0.05）.It is concluded that the growth performance of piglets fed DON-contaminated diets on 1 to 14 days of experiment is reduced, while DON adsorbent may improve the growth performance of weaner piglets and can alleviate intestine damage induced by DON.