米非司酮联合甲氨蝶呤治疗异位妊娠的临床疗效分析

Mifepristone combined with methotrexate in treatment of ectopic pregnancy

目的 探讨甲氨蝶呤联合米非司酮治疗异位妊娠的临床效果.方法 对确诊为异位妊娠患者进行回顾性分析,对照组60例采用甲氨蝶呤进行治疗;实验组60例采用甲氨蝶呤与米非司酮联合.治疗后比较两组血β-HCG值、病灶大小、住院时间及临床疗效.结果 经过治疗,实验组患者的血β-HCG值为（768.5±79.3） mIU/ml、病灶大小为（1.4±0.8） cm及住院时间为（8.3±5.9）d,对照组患者的血β-HCG值为（918.0±82.3） mIU/ml、病灶大小为（2.8±1.3） cm及住院时间为（13.1±7.8）d,两组β-HCG值、病灶大小及住院时间相比,实验组显著低于对照组,差异有统计学意义（P＜0.05）.实验组的临床治疗有效率为93.3％,对照组临床治疗有效率为75.0％,实验组显著高于对照组,差异有统计学意义（P＜0.05）.结论 应用甲氨蝶呤联合米非司酮治疗异位妊娠的实验组,临床疗效显著优于单独采用甲氨蝶呤进行治疗,在临床中值得推广应用.

Objective To explore the clinical efficacy of mifepristone combined with methotrexate in the treatment of ectopic pregnancy.Methods The data of patients with ectopic pregnancy were analyzed retrospectively.60 cases treated with methotrexate were set as a control group,and 60 cases treated with mifepristone combined with methotrexate as a treatment group.The β-HCG values,the size of mass,the hospital stays,and therapeutic efficacies were compared between the two groups after the therapy.Results The β-HCG values of the treatment group and the control group were （768.5 ± 79.3） mIU/mL and （918.0 ± 82.3） mIU/mL,respectively.The mass of the treatment group and the control group were （1.4 ± 0.8） cm and （2.8 ± 1.3） cm,respectively.The hospital stays of the treatmnent group and the control group were （8.3 ± 5.9） d and （13.1 ± 7.8） d,respectively.The β-HCG value,the size of mass,and the hospital stays of the treatment group are greatly lower than those of the control group,with statistical differences （P ＜ 0.05）.The therapeutic efficiency of the treatment group and the control group were 93.3％ and 75.0％,respectively.The therapeutic efficiency of the treatment group was significantly higher than that of the control group.Conclusions Mifepristone combined with methotrexate in the treatment of ectopic pregnancy can be popularized in clinic,which has higher therapeutic efficiency than methotrexate alone.