摘要
为研究制备盐酸沃尼妙林软膏剂及其体外透皮释药性和抗金黄色葡菌球菌感染的效果,采用乳化法分别制备W/O型和O/W型盐酸沃尼妙林软膏剂,并用高效液相色谱法测定2种软膏剂中盐酸沃尼妙林体外透皮释药率。制备的W/O型和O/W型盐酸沃尼妙林软膏剂质量均稳定,W/O型和O/W型盐酸沃尼妙林软膏剂10h的体外透皮释药率分别为30%±0.42%和18.45%±0.69%;W/O型与O/W型盐酸沃尼妙林软膏剂对金黄色葡萄球菌引起的小鼠皮下感染均有治疗效果,但W/O型软膏剂治疗效果更显著。
To study transdermal drug release ration of valnemulin hydrochloride ointments invitro and the resistant-ce to S.aureus infection,two kinds of valnemulin hydrochloride ointments,W/O and O/W,were prepared by u-sing emulsification method,the percutaneous permeability ration was determined by HPLC.Two types of valne-mulin hydrochloride ointments showed good stability;the percutaneous penetration rates of W/O and O/W oint-ments were 30%±0.42% and 18.45%±0.69% after 10 hours,respectively.Two types of valnemulin hydro-chloride ointments also showed good treatment results for subcutaneous infections caused by S.aureus in mice,but the W/O ointment shown better result than the O/W formulation.
出处
《动物医学进展》
CSCD
北大核心
2014年第5期81-84,共4页
Progress In Veterinary Medicine
基金
重庆市科委科技攻关项目(cstc2012gg-yyjsB10002-42)
