北京地区唐氏综合征产前筛查机构调查数据分析

A survey of prenatal screening institutions for Down syndrome in Beijing

目的了解北京市各唐氏综合征筛查机构工作现况及存在问题,更好地规范北京市唐氏综合征筛查工作方法。方法采用描述性统计学方法分析北京市唐氏综合征筛查机构实验室的管理、检测方法、检测设备、工作量及质控情况进行分析。结果 61家唐氏综合征筛查机构中使用孕中期三联筛查方法者占72.13%;按照卫生部行业标准的要求开展室内质控者占42.62%,室内质控合格率与该机构年筛查样本量及筛查频度均有一定关系;全市筛查实验室筛查的高风险率参差不齐,最高的为12.64%,最低的为0。结论统一北京市各机构筛查方法及方案,并按照人群需求对实验室进行合理布局,减少唐氏综合征筛查实验室数量,提高血生化筛查质量。

Objective： To investigate the work situation and problems in prenatal screening institutions for Down syndrome in Beijing, in order to seek better regulation for Down syndrome screening. Methods. A descriptive method was taken to analysis the status of management, detection method, working load and quality control of all the laborites in prenatal screening institutions in Beijing. Results： 72.13% of the 61 institutions apply the triple test in second trimester; 42.62% institutions implement internal quality control according to the professional standard issued by Health Bureau; the qualified rate of internal quality control is related to annual working load and screening frequency; the high risk rates are uneven in different laborites, with the highest one of 12.64%, and the lowest one of 0. Conclusion： Unifying the screening method and procedure, rational distribution of the labs according to the needs, and reducing the number of laborites are crucial in improving the prenatal screening quality for Down syndrome.