血清AECA、瘦素水平对子痫前期的预测价值

Relationship between serum antiendothelial cell antibodies and Leptin with preeclampsia

目的本文旨在通过研究子痫前期(preeclampsia,PE)患者及正常晚孕妇女外周血中抗内皮细胞抗体(Antiendothelial cell antibodies,AECA)、与瘦素(Leptin)的含量及相关性,探讨其在PE发病中的作用,评价其诊断价值。方法选择20例子痫前期孕妇为病例组,另选20例正常晚孕妇女为对照组,用ELISA法检测孕妇外周血AECA及瘦素水平,ROC曲线分析其诊断子痫前期的能力。结果 1.孕妇血清瘦素值,子痫前期较对照组明显升高(F=26.46,q=19.23、21.24,P<0.05);孕妇血清AECA值,子痫前期较对照组明显升高(P<0.05);2.瘦素水平与AECA在子痫前期发病中密切相关。结论血清AECA、瘦素水平升高与子痫前期的发病有关.AECA>57.7 pmol/L时诊断子痫前期的灵敏度90%,特异度90%;瘦素取值>17.05μg/L时,灵敏度80%,特异度80%;二者联合监测能更好的预测子痫前期。

Objective： To assess serum antiendothelial cell antibodies （AECA） and leptin levels as a marker for preeclampsia （PE） and to explore the possibility of AECA and leptin being a marker of severity of preeclampsia. Methods： Comparative prospective study was conducted among two groups （control and study） according to the absence or presence of clinical parameters of preeclampsia. Serum AECA and Leptin was determined using EIISA method. Results： Serum antiendothelial cell antibodies and leptin was significantly higher in preeclampsia （P〈0.05） . Conclusion： AECA and Leptin levels were found to be significantly higher among all preeclampsia patients when compared to the control group; Serum AECA and leptin in preeclampsia in the correlation suggesting that mechanisms between them, ROC curve analysis has shown that a cut off value Serum AECA〉57.7 pmol/L and Serum leptin 〉 17.05μg/L can be used to detect presence of preeclampsia.