661例孕早期胎儿超声鼻骨长度的研究

Study on 661 cases of fetal nasal bone length of early pregnancy

目的研究孕11-13周胎儿鼻骨（NB）长度的95％参考值范围及其意义。方法回顾性选择2010年1月1日至2010年9月30日在我院产检门诊就诊的单胎孕妇661例（剔除最后确诊为唐氏综合征的病例），均为孕11-13w，通过超声NB测量，计算正常11-13周胎儿鼻骨均数，标准差及95％参考值范围，第2．5百分位数。结果正常11-13周胎儿鼻骨长度均数2．847mm，标准差为0．794mm，其95％的参考值范围为2．053～3．641mm，第2．5百分位数是1．598mm。结论胎）LNB长度是进行唐氏综合征筛查的指标之一，通过计算孕早期胎儿NB长度的95％的参考值范围，为临床上唐氏综合征筛查提供数据参考并应用于孕早期血清学筛查工作，以提高唐氏筛查的准确率。

Objective： Research on 11-13 gestational weeks of fatal nasal bone （NB） length of the 95% reference range and its significance. Methods= Retrospective selected 661 singleton pregnant women （Final diagnose Down＇ s syndrome are rejected） at 11-13weeks who visit out-patient clinic for antenatal examination in January ist to September 30^th in 2010, measure fetal the length of nasal bone through ultrasound. Then calculate the mean, standard deviation, 95% limit reference value 2.5 percentile of 11-13weeks fetal nasal bone in normal Chinese. Results： The mean of 11-13weeks fetal nasal bone in normal Chinese is 2.847 mm, the standard deviation is 0.794 mm, 95% limit reference value is 2.053-3.641mm, 2.5 percentile is 1.598 mm. Conclusion： Fetal NB length is one of the indicators of screening for Down＇ s syndrome, by calculating the length of fetal NB in early stage of 95% reference range, for the clinical screening for Down＇ s syndrome and provide data reference and applied to serological screening of early pregnancy, in order to improve the accuracy rate of Down＇ s screening.