厦门地区不同职业对男性不育患者精子DNA完整性和精子参数的影响

Influence of different occupations on male infertility patients of sperm DNA integrity and sperm parameters in Xiamen area

目的探讨厦门地区不同职业对精子DNA完整性和精子参数的影响。方法将就诊的1509例男性不育患者按照职业分为司机组、计算机工作者组、工人组。将600例正常生育组做为健康对照组。采用SQA-V全自动精子分析仪进行精液常规分析,精子DNA完整性检测采用精子染色质扩散试验(SCD),以DNA断裂指数(DFI)表示。结果司机组、计算机工作者,工人组的精子密度、活动率、前向运动率和DFI与对照组比较差异有统计学意义(P<0.05);司机组和计算机工作者组的精子活动率、前向运动率、精子密度及和DFI与工人组比较差异有统计学意义(P<0.05);4组的精液量、精液pH值差异无统计学意义(P>0.05)。结论司机、计算机工作者和工人可以影响精液质量,从而导致男性不育。

Objectives： To explore the effect of different occupations on male sperm DNA integrity and sperm parameters. Methods： 1509 cases of male infertility patients will be divided into drivers, computermen and workers of 3 teams, 600 control cases were recruited for the study; sperm parameters were analysised by fully automated SQA-V sperm analyzer; Sperm DNA integrity was evaluated by sperm chromatin dispersion （SCD） , and the results were expressed interms of DNA fragmentation index （DFI） . Results： A significant difference in the concentration and mobility and forward mobility and DFI of sperm between 4 teams （P〈0.05） . A difference in the concentration and mobility and forward mobility and DFI of sperm between drivers, computermen and workers （P〈0.05） . But there is no difference in the semen volume and pH between 4 teams （P〉0.05） . Conclusion： Drivers and computermen affect routine semen parameters and soerm DNA intezritv and result in m ale infertility.