摘要
自噬是细胞内进行的一种“自我消化”的过程。在此过程中,受损的细胞结构、衰老的细胞器和变性蛋白被包裹在自噬小体中,运输到溶酶体被降解,参与细胞代谢。抗原递呈细胞(APCs)依赖自噬识别微生物,进而产生Ⅰ型干扰素。自噬不仅提供了递呈到MHC-Ⅱ类分子上的抗原肽,还参与了APC的MHC-Ⅰ类分子递呈途径。此外,自噬会降低免疫突触的稳定性。
Autophagy is a self-digestion process,in which cytopasmic orgauelles or proteins are degraded in lysosome. Autophagy is required for antigen-presenting ceils(APCs) to recognize intracellular danger signals and release type Ⅰ interferon. Autophagy not only provides a prominent source of antigens that can be loaded onto MHC- Ⅱ , but also participates in MHC- Ⅰ presentation pathway. In addition, attenuation in the formation of an immunologic synapse occurs along with the induction of autophagy.
出处
《国际免疫学杂志》
CAS
2014年第3期173-178,共6页
International Journal of Immunology
基金
国家自然科学基金(31370895)
关键词
自噬
抗原递呈细胞
抗原递呈
免疫突触
Autophagy
Antigen-presenting cells
Antigen presentation
Immunologic synapse