不同类型的调节性T细胞在类风湿关节炎中的作用

The roles of regulatory T cells in rheumatoid arthritis.

类风湿关节炎是一种系统性自身免疫性疾病，以慢性关节炎症、骨和软骨侵蚀以及滑膜组织增生为特征，目前关于RA的发病机制尚未明确。效应性T细胞即辅助性T细胞及其分泌的细胞因子的水平失衡是RA发病的重要机制，其中调节性T细胞作为一类免疫抑制性T细胞，在介导免疫稳态、维持免疫耐受及控制疾病进展方面起重要作用，因此深入研究不同亚型的Treg在RA中的功能和作用可能为RA的治疗提供新思路。

Rheumatoid Arthritis （RA） is a systemic autoimmune disease characterised by chronic inflammation of joints, bone and cartilage erosion, synovial hyperplasia. The pathogenesis of RA is not clear. The effector T cells called helper T cells and the imbalance of secreting cytokines level might be an important mechanism of RA. In addition, as a type of immune suppressing T cell, regulatory T cells （Treg） play an important role in mediating immune homeostasis and maintaining self-immune tolerance, as well as controllong the progress of diseases. Therefore, further research on the roles of different subtypes of Treg with RA may provide new ideas for the treatment of RA.