血浆同型半胱氨酸水平与颈动脉斑块相关性的研究

Relationship Between Plasma Homocysteine Level and the Carotid Plaque Formation

目的：研究血浆同型半胱氨酸水平与颈动脉斑块的相关性。方法：2012—06—01至2013—06—01在我院神经内科263例≥40岁的非脑卒中住院患者，根据血浆同型半胱氨酸水平分为正常组（n=139）和同型半胱氨酸升高组（n=124），并采用超声测定所有患者的颈动脉斑块。用单因素分析及Logistic回归分析血浆同型半胱氨酸水平与发生颈动脉斑块的关系。结果：单因素分析结果显示性别、年龄、体重指数（BMI）、吸烟、高血压病史、同型半胱氨酸是颈动脉斑块的危险因素（P〈0．05）。Logistic回归结果示，在校正了其他混杂因素后，同型半胱氨酸水平升高增加了颈动脉斑块发生的风险（优势比=1．89，95％可信区间1．01～3．55，P=0．047）。结论：血浆同型半胱氨酸水平增高是颈动脉斑块发生的独立危险因素。

Objective： To study the relationship between plasma homocysteine （Hcy） level and carotid plague formation. Methods： A total of 263 neurological patients without stroke treated in our hospital from 2012-06 to 2013-06 were studied. All patients were〉40 years and divided into 2 groups according to Hcy levels. Normal Hcy group, n=139 and High Hcy group, n=124. The carotid plaque was examined by ultrasonography and the relationship between plasma Hcy level and carotid plaque was analyzed by univariate and logistic regression analysis models. Results： Univariate analysis indicated that gender, age, BMI, smoking, history of hypertension, Hcy level were the risk factors for carotid plaque, P〈0.05. Logistic regression analysis presented that with the adjusted potential confounders, the elevated Hcy level increased the risk of carotid plaque formation, OR= 1.89, 95% CI 1.01-3.55, P=0.047. Conclusion： Elevated plasma Hcy level was the independent risk factor of carotid plaque formation.