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胰升糖素样肽-1类降糖药在心力衰竭中的治疗前景 被引量：5

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摘要 心力衰竭患者中糖尿病患病率高达40%,但心力衰竭合并糖尿病的治疗却面临极大挑战,因为传统降糖药物有些会加重心力衰竭,有些因心力衰竭合并肾功能不全而应用受限。新型调节肠促胰素类降糖药在心力衰竭合并糖尿病患者中的应用越来越受到关注,主要包括胰升糖素样肽-1(Glucagon-like peptide-1,GLP-1)类似物或其受体激动剂,和二肽基肽酶-4(dipeptidyl peptidase,DPP-4)抑制剂。GLP-1受体表达于心血管及心肌组织,且在心力衰竭时表达上调,动物实验中已显示GLP-1可能通过p38丝裂原活化蛋白激酶途径增加糖摄取改善心功能,亦有小型临床试验发现GLP-1可改善心力衰竭患者的心功能,提高射血分数、降低脑钠肽水平。以肠促胰素为靶点的降糖药物GLP-1及其受体激动剂可能是未来心力衰竭合并糖尿病患者的新选择。
作者 王运红 张宇辉 张健
机构地区 中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院心内科
出处 《中国循环杂志》 CSCD 北大核心 2014年第5期398-400,共3页 Chinese Circulation Journal
关键词 心力衰竭 糖尿病 肠促胰素GLP-1类似物 GLP-1受体激动剂
分类号 R445.1 [医药卫生—影像医学与核医学]
  • 相关文献

参考文献23

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二级参考文献22

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共引文献15

同被引文献61

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引证文献5

二级引证文献21

中国循环杂志
2014年 第5期

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