缬沙坦与依那普利对老年高血压患者室性心律失常的影响比较

Valsartan with Enalaprilat in Elderly Hypertensive Patients the Effect of Ventricular Arrhythmias

目的:比较缬沙坦与依那普利对老年高血压患者室性心律失常的影响。方法:选取2011年1月-2013年10月笔者所在医院收治的100例老年高血压合并室性心律失常患者,按照随机数字表法分为治疗组和对照组,各50例,两组患者分别采用缬沙坦和依那普利治疗,比较两种药物对老年高血压合并室性心律失常患者血压及室性心律失常发生情况的影响。结果:经过治疗后,两组患者的收缩压和舒张压均较治疗前明显降低,且差异有统计学意义(P<0.05)。但治疗后两组收缩压、舒张压比较差异无统计学意义(P>0.05)。治疗组治疗后发生室性心律失常次数较治疗前明显减少,与对照组治疗后比较亦明显降低,差异有统计学意义(P<0.05)。对两组患者室性心律失常减少的相关因素进行相关性分析,对照组患者的室性心律失常减少与收缩压、舒张压下降及左室心肌质量指数降低密切相关;治疗组室性心律失常减少则与收缩压、舒张压下降及左室心肌质量指数降低无相关性。结论:使用缬沙坦治疗老年高血压并室性心律失常患者,不仅可有效地控制血压,而且可以有效减少室性心律失常的发生,不良反应少,患者易于接受,值得临床推广应用。

Objective： To comparative valsartan and enalaprilat ventricular arrhythmias in patients with senile hypertension. Method ： Selection in the author＇s hospital from January 2011 to October 2013 treated 100 cases of elderly patients with hypertension with ventricular arrhythmia, according to random number table method was divided into treatment group and control group, 50 cases each, two groups of patients treated with valsartan and enalaprilat respectively, compared two drugs on blood pressure in elderly patients with hypertension combined veutricular arrhythmia and ventricular arrhythmia occurrence.Result： After treatment, two groups of patients with systolic and diastolic blood pressure were significantly lower than before treatment, and the difference was statistically significant （P〈0.05）. But systolic pressure, diastolic pressure between the two groups after treatment had no statistical significance （P〉0.05）. The treatment group after treatment was significantly reduced the occurrence of ventricular arrhythmia times, compared with the control group after treatment also significantly reduced, the difference was statistically significant （P〈0.05）. Ventricular arrhythmias in patients with two groups of reduce the related factors of the correlation analysis, the control group of patients with ventricular arrhythmia less and systolic pressure, diastolic pressure drops, and left ventricular myocardium closely related to the quality index was lower; ventricular arrhythmia treatment group reduced with systolic pressure, diastolic blood pressure decreased and the left ventricular myocardial quality index decrease no correlation.Conclusion： The use of valsartan treatment in elderly patients with hypertension and ventricular arrhythmia, not only can effectively control the blood pressure, and can effectively reduce the occurrence of ventricular arrhythmia, less adverse reactions, patients are easy to accept, worthy of clinical popularization and application.