血清adropin蛋白水平与冠心病的相关性

Correlation of serum adropin level with coronary artery disease

目的 探讨血清adropin蛋白水平与冠心病的相关性.方法 选择2011年1月至2012年7月因胸痛、胸闷首次于苏州大学附属第二医院就诊的患者356例,根据冠状动脉造影结果分为冠心病组（264例）与对照组（92例）.测定血清adropin、高敏C反应蛋白、空腹血糖、空腹血浆胰岛素浓度.冠心病组患者计算SYNTAX得分.结果 冠心病组患者的血清adropin浓度明显低于对照组[（56±15）比（83±10） ng/L,P＜0.01].SYNTAX低分组、中分组、高分组患者的血清adropin浓度分别为（60±22）、（56±12）、（54±10） ng/L,3组间差异无统计学意义（P=0.116）.多因素Logistic回归分析显示低血清adropin水平是冠心病发病的独立危险因素（OR=0.849,95％ CI：0.817～0.882,P＜0.01）.结论 低血清adropin水平与冠心病具有相关性,adropin可能在冠心病的发病中起保护作用.

Objective To explore the correlation of serum adropin level with coronary artery disease （CAD）.Methods According to coronary angiography,356 consecutive patients with chest complaints from January 2011 to July 2012 were divided into 2 groups of CAD （n =264,with CAD） and control （n =92,without CAD）.The serum adropin level and other CAD related metabolic parameters were measured and SYNTAX score was calculated.Results Serum adropin level was significantly lower in group CAD than that in control group （（56 ± 15） vs （83 ± 10） ng/L,P ＜ 0.01）.Serum adropin levels in high,mild,low SYNTAX score group were （60 ± 22）,（56 ± 12）,（54 ± 10） ng/L respectively,and there was no significant difference among 3 groups（P =0.116）.Multivariate regression analysis revealed that adropin was an independent risk factor for CAD （OR =0.849,95％ CI：0.817-0.882,P ＜0.01）.Conclusions Lower serum adropin level is significantly associated with CAD.Thus it indicates a possible role of adropin in the prevention of CAD.