静电纺丝纳米纤维在骨组织工程中的应用

Electrospun composite nanofibers for bone tissue engineering

静电纺丝纳米纤维技术在生物医学领域有着广泛的应用研究,其在骨组织工程应用中仍未解决的问题是同时满足材料的生物相容性、可降解性、生物活性和力学性能。骨组织工程主要构成要素是支架、细胞和生长因子。静电纺丝复合纳米纤维支架材料具有纳米级别的天然骨分级结构和天然骨的多孔结构,改进复合支架材料可促进细胞的浸润生长、干细胞分化和组织形成。本文重点探讨通过静电纺丝技术改进复合支架的性能,及其在动物实验研究方面的最新进展。

Electrospun composite nanofibers have been widely used in biomedical fields. There are still some unresolvedproblems which simultaneously satisfy the material bioeompatibility, biodegradability, mechanical properties and biological activity. Bone tissue engineering mainly consists of sacffolds, cells and growth factors. Eleetrospun composite nanofibers, which areporous and hierarchical, can promote cell growth and invasion by improving the performance of scaffolds. This paper also intro-duces the advanced applications in the study of animal experiments.