宿主p53基因多态性与HPV16感染、宫颈癌发生发展的相关性

Correlation of Host p53 Genetic Polymorphism with HPV16 Infection and Development of Cervical Cancer

目的研究宿主p53基因多态性(p53基因第4外显子72位密码子,rs1042522)与HPV16感染、宫颈癌发生发展的相关性.方法采用TaqMan SNP Genotyping Assays方法进行p53基因多态性(p53基因第4外显子72位密码子)分析.结果 p53基因第4外显子72位密码子的基因型频率和等位基因频率在病例组与HPV16感染组、对照组之间差异有统计学意义(P<0.01);但基因型频率和等位基因频率在对照组与HPV16感染组之间无统计学差异,P值分别为0.924和0.870.结论 p53基因第4外显子72位密码子突变与HPV16感染无明显相关性,但是该突变与宫颈癌的发生有相关性.

Objective To study the correlation of host p53 genetic polymorphism （the 4th Exon of 72 codon in p53 gene） with HPV16 infection and the development of cervical cancer.Methods The TaqMan SNP Genotyping Assays method was used to analyze the p53 gene polymorphism （p53 gene exon 4 of 72 codon）.Results In the gene frequency of p53 gene SNP-rs1042522 and allele frequency,there were statistical differences between the case group and HPV16 infection group,the control group,with the P-value of 0.001 and ＜ 0.001 respectively,while no statistical differences between the control group and HPV16 infection group,with the P-value of 0.924 and 0.870 respectively.Conclusion There is no obvious correlation between the SNP-rs1042522 C/G mutation of the p53 gene and the HPV16 infection,but the mutation has some relevance to the occurrence of cervical cancer.