颈部肌力失衡对年青大鼠髁突生长发育的影响

Effect of Cervical Muscle Imbalance on the Growth and Development of Rat Condyle

目的探讨颈部肌力失衡是否会影响髁突的发育.方法 18只4周龄SD大鼠,分为手术侧组(去除部分胸锁乳突肌)、对侧组及空白对照组.于术后1,3,5周处死,组织学观察髁突形态变化,免疫组化及TUNEL观察软骨细胞增殖与凋亡情况.结果 PCNA阳性细胞术后3周,肥大层阳性细胞数手术侧与非手术侧及空白组有差异.凋亡细胞数不同时间点及不同组数未见到显著性差异.结论颈部肌力失衡在一定程度内对髁突软骨细胞增殖有影响,但对髁突的发育影响不明显.

Objective The aim was to explore whether the cervical muscle imbalance affect the growth and development of condyle or not.Methods Eighteen 4-week-old male rats were randomly divided into three groups：the experimental group （surgically induced unilateral sternocleidomastoid removal）,the contralateral sides group,and the blank control group （nooperation）.The rats were killed at intervals up to 5 weeks after surgery,then the morphological changes of condyle were observed by histological observation,and the proliferation and apoptosis of cartilage cells were observed using immunohistochemistry and TUNEL.Results There were significant differences in PCNA positive cell count among three groups in three weeks after operation.However,there was no significant difference in apoptotic cell count among groups.Conclusion Cervical muscle imbalance had effects on condylar cartilage cell proliferation in some degree,while no effects on the growth of condyle.