摘要
目的研究乙肝合并NAFLD患者肝功能及病毒复制与脂代谢水平相关性.方法选择乙型肝炎患者138例,分为有患者分为慢性乙型肝炎组(A组)及慢性乙型肝炎合并NAFLD组(B组),分别有65例、73例,同时选择50名健康人群作为对照组(C组).分别检测肝功能肝功能、HBV-DNA及血清脂肪因子水平.结果A组较C组ALT及AST差异有统计学意义(P<0.05),B组较A组及C组ALT及AST差异有统计学意义(P<0.05).A组较C组Chemerin、内脂素、瘦素水平差异有统计学意义(P<0.05),B组较A组及C组Chemerin、内脂素、瘦素水平均差异有统计学意义(P<0.05).Chemerin及瘦素与ALT、AST呈正相关(P<0.05),内脂素与AST呈正相关(P<0.05).结论乙肝合并NAFLD患者肝功能与脂代谢紊乱具有较好的相关性,两者共同参与了NAFLD的形成.
Objective To investigate the correlation of liver function and viral replication with lipid metabolism in patients with hepatitis B and NAFLD.Methods One hundred and thirty-eight cases of hepatitis B patients were divided into chronic hepatitis B group (group A,65 cases) and chronic hepatitis B with NAFLD group (group B,73 cases),while 50 healthy people were selected as a control group (group C).Liver function,HBV-DNA and serum adipokine levels were detected.Results ALT,AST,chemerin,visfatin,and leptin levels in group A were significantly increased compared with group C (P<0.05),and in group B were significantly increased compared with groups A and C (P<0.05).Chemerin and leptin showed significant positive correlations with ALT and AST (P<0.05),and visfatin showed significant positive correlation with AST (P<0.05).Conclusion Liver function in patients with NAFLD has a good correlation with dyslipidemia,which participate in the formation of NAFLD.
出处
《昆明医科大学学报》
CAS
2014年第5期111-113,共3页
Journal of Kunming Medical University
基金
陕西省科技攻关基金资助项目(2007k15-05)
关键词
乙肝
NAFLD
肝功能
脂代谢
Hepatitis B
NAFLD
Liver function
Lipid metabolism