乙肝合并NAFLD患者肝功能及病毒复制与脂代谢水平相关性分析

Correlation of Liver Function and Viral Replication with Lipid Metabolism in Patients with Hepatitis B and NAFLD

目的研究乙肝合并NAFLD患者肝功能及病毒复制与脂代谢水平相关性.方法选择乙型肝炎患者138例,分为有患者分为慢性乙型肝炎组(A组)及慢性乙型肝炎合并NAFLD组(B组),分别有65例、73例,同时选择50名健康人群作为对照组(C组).分别检测肝功能肝功能、HBV-DNA及血清脂肪因子水平.结果A组较C组ALT及AST差异有统计学意义(P<0.05),B组较A组及C组ALT及AST差异有统计学意义(P<0.05).A组较C组Chemerin、内脂素、瘦素水平差异有统计学意义(P<0.05),B组较A组及C组Chemerin、内脂素、瘦素水平均差异有统计学意义(P<0.05).Chemerin及瘦素与ALT、AST呈正相关(P<0.05),内脂素与AST呈正相关(P<0.05).结论乙肝合并NAFLD患者肝功能与脂代谢紊乱具有较好的相关性,两者共同参与了NAFLD的形成.

Objective To investigate the correlation of liver function and viral replication with lipid metabolism in patients with hepatitis B and NAFLD.Methods One hundred and thirty-eight cases of hepatitis B patients were divided into chronic hepatitis B group （group A,65 cases） and chronic hepatitis B with NAFLD group （group B,73 cases）,while 50 healthy people were selected as a control group （group C）.Liver function,HBV-DNA and serum adipokine levels were detected.Results ALT,AST,chemerin,visfatin,and leptin levels in group A were significantly increased compared with group C （P＜0.05）,and in group B were significantly increased compared with groups A and C （P＜0.05）.Chemerin and leptin showed significant positive correlations with ALT and AST （P＜0.05）,and visfatin showed significant positive correlation with AST （P＜0.05）.Conclusion Liver function in patients with NAFLD has a good correlation with dyslipidemia,which participate in the formation of NAFLD.