男性肥胖骨质疏松患者性激素与骨代谢水平及相关性分析

Bone Betabolism and Sex Hormone Levels and Their Correlation in Obese Patients with Osteoporosis

目的探讨男性肥胖骨质疏松患者性激素与骨代谢水平及相关性分析.方法选择男性骨质疏松患者76例,其中肥胖合并骨质疏松39例(A组)、单纯骨质疏松37例(B组),另选择健康男性40例作为对照组(C组).分别检查3组患者骨代谢指标、血脂及性激素.结果 A组CTX-1、BGP较B、C组差异有统计学意义(P<0.05),B组CTX-1、BGP较C组差异有统计学意义(P<0.05).A组TG、TC、HDL、LDL较B、C组差异有统计学意义(P<0.05),B组LDL较C组差异有统计学意义(P<0.05).A组TT、E2较B、C组差异有统计学意义(P<0.05).TT与CTX-1、BGP显著相关(P<0.05).E2与CTX-1、BGP显著相关(P<0.05).结论肥胖所致TT低下及E2升高与骨代谢存在密切关系,积极控制肥胖程度有助于降低骨质疏松发生率.

Objective To study bone metabolism and hormone levels and their correlation in obese patients with osteoporosis.Methods 76 patients with osteoporosis included 39 cases of obesity with osteoporosis （A group ）,37 cases of osteoporosis alone （B group）,and the other 40 cases of healthy men were selected as the control group （C group） 3 groups of patients were examined three indicators of bone metabolism,lipids and sex hormones.Results CTX-1,BGP of A group was significantly higher than B,C group （P＜0.05）,CTX-1,BGP of B group was significantly higher than the C group （P＜0.05）.TG,TC,HDL,LDL of A group had significant difference with B,C group （P＜0.05）,LDL of B group was significantly higher than the C group （P＜ 0.05）.TT,E2 of A group had a significant difference with B,C group （P ＜0.05）.TT and CTX-1,BGP was significantly correlated （P ＜0.05） E2 and CTX-1,BGP showed significant correlation （P ＜0.05） Conclusion Obesity caused elevated E2 and decreased TT has a close relationship with hone metabolism,actively controlling the degree of obesity can help reduce the incidence of osteoporosis.