PIH患者血清D-二聚体及内皮素与脂肪因子水平及相关性研究

Correlation Analysis of Serum D-dimer,Endothelin and Adipokines in Patients with PIH

目的探讨妊娠高血压综合征患者血清D-二聚体及内皮素与脂肪因子关系及临床意义.方法选择PIH患者94例,分为轻度组42例、中度组34例、重度组18例.同时选择同期行健康体检的30例研究对象为对照组.分别检测各组的Chemerin、内脂素、瘦素及D-二聚体、内皮素的值,并进行统计学处理.结果轻度组患者Chemerin、内脂素较对照组差异有统计学意义(P<0.05),中度组患者Chemerin、内脂素、D-二聚体、内皮素较对照组及轻度组患者差异有统计学意义(P<0.05),瘦素较对照组差异有统计学意义(P<0.05).重度组患者Chemerin、内脂素、D-二聚体、内皮素较对照组及轻度组、中度组患者差异有统计学意义(P<0.05),瘦素较对照组、轻度组差异有统计学意义(P<0.05).D-二聚体与Chemerin及内脂素呈正相关(P<0.05),内皮素与Chemerin、内脂素、瘦素正相关(P<0.05).结论脂肪因子代谢紊乱是PIH发生的重要原因,并与血管内皮功能及凝血、纤溶系统密切相关.

Objective To investigate the correlation of serum D-dimer,endothelin and adipokines in patients with PIH.Metlhods 94 PIH patients were divided into three groups：mild group,moderate group and severe group,there were 42 cases,34 cases,18 cases,respectively.30 cases of healthy subjects were selected as controls.Chemerin,the fat hormone,leptin,and D-dimer,endothelin were detected.Results Chemerin,visfatin in the mild patients compared with the control group significantly increased （P＜0.05）,Chemerin,visfatin,D-dimer,endothelin in moderate patients group compared with the control group and mild patients were increased （P＜0.05）,leptin was significantly higher than the control group （P＜0.05）.Chemerin,visfatin,D-dimer,endothelin group of severe patients compared with the control group and the mild,moderate patients were increased （P＜0.05）,leptin was significantly higher than the control group,mild group （P＜0.05） D-dimer and Chemerin and visfatin showed significant positive correlation （P＜0.05）,endothelin and Chemerin,visfatin,leptin was significantly positively correlated （P＜0.05）.Conclusion Adipokines are important reason for PIH occurrance and are closely related to endothelial function and coagulation,fibrinolytic system.