摘要
多肽药物因具有相对成本低,生物活性强,副作用小,不蓄积中毒,作用靶点专一等特点而被人们广泛应用。但天然存在的多肽类药物含量较少、纯度较低,无法满足临床的需求。经研究发现,通过体外合成的多肽药物具有合成周期短、生产量大等优势,能够有效克服天然多肽药物的不足,对于推广多肽类药物的应用有重要意义。本文对多肽类药物体外合成方法进行综述,为其今后的发展和临床应用提供参考。
Peptide drugs have been widely used for the low cost , high biological activity, low side effects, no accumulation of toxic, target specificity and other s .However, the natural peptide drugs have low concentration and low purity;can not meet the requirement of clinical applications .Synthetic peptide drugs have the priority of short synthetic cycle and large production volume , which are important for the promotion of clinical application of peptide drugs .Consulting the relevant literatures , this article intends to review the drugs synthesis and provide a reference for future drug development and clinical application .
出处
《大连医科大学学报》
CAS
2014年第2期177-181,共5页
Journal of Dalian Medical University
基金
大连市科技计划项目(2011E12SF029)
关键词
多肽药物
体外合成
化学合成
基因重组
peptide drugs
in vitro synthesis
chemical synthesis
genetic recombinant