摘要
脑梗死的病理生理过程实质上是在动脉粥样硬化的基础上发生的局部脑组织缺血坏死的过程。脑缺血可引起一系列复杂的导致血管源性水肿的病理变化，包括谷氨酸的释放、白细胞浸润和血一脑屏障的破坏。在实验脑缺血模型中发现，基质金属蛋白酶参与了基底膜和细胞外基质的破坏。
出处
《卒中与神经疾病》
2014年第2期120-122,共3页
Stroke and Nervous Diseases
参考文献21
-
1Murphy G, Nagase H. Progress in matrix metalloproteinase re- search. Mol Aspects Med, 2008,29 (5) .- 290-308.
-
2Wang GM, Guo QM, Hossain M, et al. Bone marrowderived cells are the major source of MMP-9 contributing to blood - brain barrier dysfunction and infarct formation after ischemic stroke in mice. Brain Res, 2009,1294.. 183-192.
-
3Zhao X, Benveniste EN. Transcriptional Activation of human ma- trix metalloproteinase-9 gene expression by multiple Co-activa- tors. J Mol Biol, 2008,383 (5) : 945-956.
-
4Candelario-Jalil E, Yang Y, Rosenberg GA. Diverse roles of ma- trix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience, 2009, 158(3) : 983-994.
-
5Gu Z, Kaul M, Yan B, et al. S-nitrosylation of matrix metallopro- teinases:Signaling pathway to neuronal cell death. Science, 2002, 297(5584) : 1186-1190.
-
6Manabe S,Gu Z, Lipon SA. Activation of matrix metalloprotein- ase-9 via neuronal nitric oxide synthase contributes to NMDA-in- duced retinal ganglion cell death. Invest Ophthalmol Vis Sci, 2005,46 (12) : 4747-4753.
-
7Dwivedi A, Slater SC, George SJ. MMP-9 and -12 cause N-cad- herin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation. Cardiovasc Res, 2009, 81 ( 1 ) : 178-186.
-
8Speidl WS, Toiler WG, Kaun C, et al. Catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human mono- cytes and in the human monocytic cell line U937: possible impli- cations for peri-operative plaque instability. FASEB J, 2004, 18 (3) : 603-605.
-
9Robertson L, Grip L, Mattsson HL, et al. Release of protein as well as activity of MMP-9 from unstable atherosclerotic plaques during percutaneous coronary interventiorL J Intern Med , 2007, 262 (6) : 659-667.
-
10Chela KC,Wang YS, Hu CY, et al. OxLDL up-regulates microR- NA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes., a novel mechanism for cardiovascular diseases. FASEB J,2011,25 (5) : 1718-1728.
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-
1刘昱言,刘轲,刘敬霞,李建生.基质金属蛋白酶-2、-9与脑缺血微血管损伤的关系[J].中国老年学杂志,2014,34(1):257-259. 被引量：5
-
2胡晓松,周东,唐瑜,刘静,李娟.层粘连蛋白及基质金属蛋白酶-9在大鼠局灶性脑缺血梗死区周围的表达及意义[J].华西医学,2013,28(5):651-654. 被引量：5
-
3廖君,张薇,夏兴,石咏梅,陈安,葛金文.脑泰方对局灶性脑缺血大鼠脑组织核因子-κB、基质金属蛋白酶9及其抑制剂表达的影响[J].中国中医药信息杂志,2013,20(9):28-30. 被引量：10
-
4孔立红,杨荣美,孟培燕,王洋岗,周华,徐珉.可转形穴位注射药线对脑缺血再灌注大鼠皮质区MMP-9和TIMP-1的影响[J].时珍国医国药,2013,24(9):2308-2310. 被引量：5
-
5刘宏丽,孙丽敏,鲍晓娟,崔志杰,滕伟禹.普罗布考对大鼠脑出血后MMP-9表达及血-脑屏障通透性的影响[J].脑与神经疾病杂志,2014,22(1):50-53. 被引量：2
-
1李振环.探究社区康复对脑卒中患者日常生活活动能力与运动功能的影响[J].中国医疗器械信息,2015,21(03Z):222-222.
-
2吕莹.缺血性脑卒中的诊断与早期治疗[J].中国临床医生杂志,2007,35(9):71-74. 被引量：6
-
3袁健红.浅议缺血性脑卒中早期治疗[J].中医临床研究,2009,1(23):60-61.
-
4车晓林,刘巍,张百平,廖响辉.小脑幕切迹疝致大脑后动脉闭塞16例分析[J].实用医技杂志,2007,14(26):3570-3572.
-
5康亚秋,李柱一,张来启,游国雄.脊髓蛛网膜炎病因、临床及MRI[J].中风与神经疾病杂志,2000,17(6):370-371. 被引量：1
-
6无,王玉洁（译）,白璇（译）,李新辉（译）,刘娟（译）,王健（译）,邓荣华（译）.缺血性卒中和短暂性脑缺血发作处理指南2008[J].中华脑血管病杂志（电子版）,2008,2(4):214-256. 被引量：9
-
7无,王玉洁(译),白璇(译),李新辉(译),刘娟(译),王健(译),邓荣华(译).缺血性卒中和短暂性脑缺血发作处理指南2008[J].国际脑血管病杂志,2008,16(6):401-440. 被引量：39
-
8周冬青,高书荣,朱晴晖,刘德琮.可溶性细胞间黏附分子-1在脑梗死治疗前后的变化[J].老年医学与保健,2009,15(5):309-310.
-
9陈荣伟,段诚凤.对依赖综合征诊断标准的商榷[J].临床精神医学杂志,2002,12(3):172-172. 被引量：2
-
10张红.他巴唑依赖状态64例报告[J].中国行为医学科学,2001,10(6):567-567. 被引量：1
