磁液悬浮离心血泵体外溶血的实验及耐久性实验

In Vitro Hemolysis Test and Durability Test of Magnetic and Hydrodynamic Levitation Blood Pump

通过建立模拟循环管路系统来研究磁液悬浮离心血泵的溶血性能及机械稳定性。建立体外模拟循环管路系统,体外溶血实验中以新鲜羊血为循环介质,调节前负荷和后负荷分别为15、100 mmHg,血泵转速设定为2 900 rpm,测定血浆游离血红蛋白含量(FHb)和红细胞压积(Hct),计算血泵标准溶血指数(NIH);耐久性试验其他各项设定同体外溶血实验,循环介质改为甘油水溶液。在体外溶血实验中,测得磁液悬浮离心血泵NIH值为(0.0038±0.0008)g/100L;耐久性实验中血泵连续正常运转90 d,期间无卡壳、停泵等现象,电压、电流、转速稳定。该血泵溶血性能处于较高水平,机械性能稳定可靠,满足进一步进行动物实验的要求。

To study the hemolytic performance and durability of magnetic and hydrodynamic levitation blood pump by using vitro circulation loop system. The vitro circulation loop system was established. In vitro hemolysis test,the fresh sheep blood was collected as the circulating medium,the speed of blood pump was adjusted to 2 900 rmp,the preload and afterload were set at 15,100 mmHg,plasma free hemoglobin（ FHB） and hematokrit（ Hct） were detected,then the normalized index of hemolysis（ NIH） was calculated. In the durabilyt test,all the materials and environment settings were as same as them in vitro hemolysis test except the medium replaced by glycerin water. The blood pump had operated for 90 d continuoustly and recorded its performance. In vitro hemolysis test,the NIH was（ 0. 0038 ±0. 0008） g/100L. In durability test,the blood pump operated smoothly and stably without being stucked and shut down. The magnetic and hydrodynamic levitation blood pump has good hemolytic performance and stable mechanical property that can meet the need for animal experiments.