慢性束缚应激诱导自发性高血压大鼠出现抑郁焦虑样行为

Chronic Restraint Stress Induced Anxiety-and Depression-like Behaviors in Spontaneously Hypertensive Rats

目的 探讨自发性高血压大鼠（SHR）在慢性束缚应激（Chronic Restraint Stress,CRS）时抑郁焦虑样行为学改变. 方法 雄性SHR大鼠16只,随机分为对照组（CON,n=8）和慢性束缚应激组（CRS,n=8）.通过旷场试验（Open Field test,OFT）、强迫游泳实验（Forced Swimming test,FST）、高架十字迷宫试验（Elevated Plus Maze,EPM）评价其抑郁焦虑样行为,同时比较SHR血压变化及血清ACTH水平.结果 束缚4周后,与对照组相比,CRS组的SHR在OFT中直立次数及总位移均显著降低（P＜0.05）,FST中不动时间显著延长（P＜0.05）,EPM中开臂滞留时间百分比显著下降（P＜0.05）. 结论 慢性束缚应激可诱导SHR出现抑郁焦虑样行为.

Objective To investigate the effects of chronic restraint stress （CRS） on anxiety- and depression-like behaviors in Spontaneously Hypertensive Rats（SHR）. Methods SHR were randomly divided into control（CON） group and CRS group respectively. The changes of behaviors were detected by open field test （OFT）,forced swimming test （FST） and elevated plus maze（EPM） test￡-he changes of blood pressure and levels of adrenocorticotropic hormone（ACTH） in plasma in different groups were also measured and compared. Results SHR in CRS group showed significant reductions in rearing incidence in OFT（P￡1/4 0.05）,the time spent in open arms during the EPM（P￡1/4 0.05）, and the immobility during the FST was increased significantly （P￡1/4 0.05）. Furthermore, the blood pressure and concentra- tion of plasma ACTH increased significantly in CRS group compared to CON group. Conclusions CRS can induce anxiety- and depression-like behaviors in SHR.