胺碘酮对急性心肌梗死老年患者合并心房颤动的疗效分析

Effcacy of Amiodarone on acute myocardial infarction and atrial fibrillation in elderly patients

目的 观察应用胺碘酮治疗急性心肌梗死（AMI）合并心房颤动（AF）的疗效. 方法 选取2009年1月至2013年6月的AMI合并AF老年患者108例,数字抽签随机分为对照组和治疗组,每组54例.对照组患者采用毛花苷（西地兰）治疗,治疗组患者采用胺碘酮治疗.比较两组患者接受治疗后AF控制率、窦性心律维持率及不良反应情况. 结果 治疗组患者在治疗后6h、12h、24 h和48 h的AF控制率均低于对照组,差异有统计学意义（x2值分别为5.173、5.066、4.757、6.684,均P＜0.05）.治疗组患者窦性心律维持有效47例高于对照组24例（x2=21.748,P＜0.01）;治疗组不良反应率低于对照组（Z=15.621,P＜0.01）. 结论 胺碘酮治疗老年人AMI并发AF效果和安全性优于单独使用西地兰.

Objective To investigate the the effect of Amiodaroneo on acute myocardial infarction （AMI） and atrial fibrillation （AF） in elderly patients,and provide the basis for the treatment.Methods A total of 108 patients with AMI and AF in our hospital from January 2009 to June 2013 were collected and randomly divided into control and experimental groups,each group of 54 cases.The control group was treated with cedilanid and the experimental group were treated with amiodarone.AF control rate,sinus rhythm maintenance rate and adverse reactions of the two groups were analyzed and compared after treatment.Results The AF control rate of experimental group was significantly higher than that of control group in 6 h,12 h,24 h and 48 h after treatment （x2=5.173,5.066,4.757,6.684,P〈0.05）.Sinus rhythm maintenance rate of experimental group was increased compared with control group （47 cases vs.24 cases,x2=21.748,P〈0.01）.Adverse reaction rates of the experimental group was lower than the control group （x2 =15.621,P〈0.01）.Conclusions The treatment of AMI and AF by amiodarone is betterr and safe than cedilanid alone,so it is worth popularizing and applying on clinic.