摘要
目的：探索转化生长因子（TGF）-β1基因多态性与我国人群乙型肝炎肝硬化的关系。方法计算机检索中国生物医学文献数据库、重庆维普中文科技期刊全文数据库、清华CNKI数据库、万方科技期刊全文数据库、Pubmed，检索时间范围为建库到2013年7月。按纳入、排除标准选择TGF-β1基因509位点、869位点基因多态性与乙型肝炎肝硬化关系的病例对照研究。应用RevMan 5.1软件对纳入的研究进行定量分析。结果共纳入6个病例对照研究。Meta分析结果显示509位点携带T等位基因的乙型肝炎肝硬化合并OR值为1.02，95%CI为（0.67~1.54）， CT和TT基因型者乙型肝炎肝硬化合并OR值为0.80，95%CI为（0.36~1.78）；869位点携带C等位基因的乙型肝炎肝硬化的合并OR值为1.05，95%CI为（0.69~1.62），TC和CC基因型者乙型肝炎肝硬化的合并OR值为0.98，95%CI为（0.48~2.00）。未发现显著发表偏倚。结论未发现中国人群中TGF-β1基因多态性与乙型肝炎肝硬化有关系。
Objective To evaluate the relationship between genetic polymorphism of transforming growth factor （TGF）-β1 and susceptibility of liver cirrhosis after hepatitis B virus infection in Chinese population. Methods CBM, VIP, CNKI, Wanfang technological periodical full-text databases and Pubmed from set up to July, 2013 were electronically searched to identify case-control studies on the relationship between genetic polymorphism of TGF-β1 promoter 509 site, co-don 869 site and liver cirrhosis after hepatitis B virus infection. The data were quantitatively analyzed by RevMan 5.1 soft-ware after assessing the quality of included studies. Results Six case-control studies were selected for Meta-analysis based on our inclusion and exclusion standards. The results of Meta-analysis showed that the pooled OR value for liver cir-rhosis among Chinese patients after hepatitis B virus infection with T allele of TGF-β1 gene at promoter 509 was 1.02 （95%CI：0.67-1.54）, the pooled OR values for patients with TT and CT genotypes were 0.80 （95%CI：0.36-1.78）. OR values for pa-tients with C allele of TGF-β1 gene at codon 869 was 1.05 （95%CI：0.69-1.62）, the pooled OR values for patients with CC and CT genotypes were 0.98 （95%CI：0.48-2.00）. No significant publication bias was found. Conclusion The genetic poly-morphism of TGF-β1 at promoter 509 and codon 869 showed no association with susceptibility of liver cirrhosis after hepati-tis B virus infection in Chinese population.
出处
《天津医药》
CAS
北大核心
2014年第5期502-506,共5页
Tianjin Medical Journal
