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ST段抬高急性心肌梗死患者血清氧化低密度脂蛋白抗体-IgM水平与冠状动脉病变程度及住院期间预后的相关研究 被引量:4

Serum autoantibodies against oxidized low-density lipoprotein IgM in patients with ST-segment elevation acute myocardial infarction: correlations with coronary lesions and in-hospital prognosis
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摘要 目的:探讨血清氧化低密度脂蛋白抗体-IgM(ox-LDL-Ab IgM)水平在ST段抬高急性心肌梗死(STEMI)患者中与冠状动脉病变程度及近期预后的相关性。方法选取2008年8月至2009年5月诊断明确并行急诊经皮冠状动脉介入(PCI)治疗的STEMI患者95例,根据冠状动脉造影结果分为单支病变组、双支病变组及三支病变组,并以Gensini积分评价冠状动脉狭窄程度,分别测定血清ox-LDL-Ab IgM、丙二醛(MDA)、血脂,计算体质量指数(BMI),统计患者住院期间心血管事件发生情况,分析ox-LDL-Ab IgM水平与冠状动脉病变程度及近期预后的关系。结果 STEMI患者血清ox-LDL-Ab IgM水平随冠状动脉病变支数增加而降低(P<0.05),但与Gensini积分无明显相关性(P>0.05);ox-LDL-Ab IgM水平与血脂、血糖水平等无明显相关性(P>0.05),与MDA水平呈显著负相关(r=-0.319,P<0.05);ox-LDL-Ab IgM水平与患者住院期间心血管事件发生率呈显著负相关(r=-0.708,P<0.05),logistic回归分析显示, ox-LDL-Ab IgM是STEMI患者住院预后的保护因素(OR=-0.588,P<0.05)。结论血清ox-LDL-Ab IgM水平可在一定程度上反映STEMI患者冠状动脉病变的严重程度。其可能通过调节机体氧化应激水平,减少LDL氧化修饰生成ox-LDL,从而减轻冠状动脉粥样硬化的面积,可能对STEMI患者近期预后具有保护作用。 Objective To investigate the relationship of serum autoantibodies against oxidized low-density lipoprotein IgM (ox-LDL-Ab IgM) with coronary lesions and clinical prognosis in patients with ST-segment elevation acute myocardial infarction (STEMI). Methods From August 2008 to May 2009, 95 patients with STEMI undergoing elective coronary angiography (CAG) and emergent percutaneous coronary intervention (PCI) were enrolled in the study. All patients were divided into single-, double- and triple-vessel lesion groups according to the numbers of vessels with significant stenosis. The ox-LDL-Ab IgM, maleic dialdehyde (MDA), serum lipids, body mass index (BMI), Gensini’s score, and cardiovascular events during hospitalization were recorded and calculated. The relationship of serum level of ox-LDL-Ab IgM with coronary lesions and short-term prognosis was analyzed. Results The serum level of ox-LDL-Ab IgM was reduced with the increase in stenostic vessel numbers in STEMI patients (P〈0.05), but had no correlation with Gensini’s score (P〉0.05). The serum level was negatively correlated with serum MDA (r=-0.319, P〈0.05), but no obvious correlation was found with serum lipids and blood glucose (P〉0.05). There was negative correlation between the serum level of ox-LDL-Ab IgM and cardiovascular events during hospitalization (r=-0.708, P〈0.05). Logistic linear regression analysis showed that ox-LDL-Ab IgM was a protective factor for patients with STEMI (OR=-0.588, P〈0.05). Conclusion The serum level of ox-LDL-Ab IgM reflects the severity of atherosclerosis in patients with STEMI. ox-LDL-Ab IgM may reduce modification of LDL to ox-LDL through regulating oxidative stress, and then attenuates the coronary atherosclerosis area. It may play a protective role in the short-term prognosis in STEMI patients.
出处 《中华老年多器官疾病杂志》 2014年第4期268-273,共6页 Chinese Journal of Multiple Organ Diseases in the Elderly
关键词 冠状动脉疾病 GENSINI积分 ST段抬高急性心肌梗死 氧化低密度脂蛋白抗体 coronary disease Gensini's score ST-segment elevation acute myocardial infarction anti-oxidized low-densitylipoprotein antibody
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  • 1Leeuwenburgh C, Rasmussen JE, Hsu FF, et al. Massspectrometric quantification of markers for proteinoxidation by tyrosyl radical, copper, and hydroxyl radicalin low density lipoprotein isolated from humanatherosclerotic plaques[J]. J Biol Chem, 1997, 272(6):3520-3526.
  • 2Gensini GG. A more meaningful scoring system fordetermining the severity of coronary heart disease[J]. Am JCardiol, 1983, 51(3): 606.
  • 3Stemme S, Hansson GK. Immune mechanisms inatherogenesis[J]. Ann Med, 1994, 26(3): 141-146.
  • 4Hansson GK, Bondjers G, Bylock A, et al. Ultrastructuralstudies on the localization of IgG in the aortic endotheliumand subendothelial intima of atherosclerotic andnonatherosclerotic rabbits[J]. Exp Mol Pathol, 1980, 33(3):302-315.
  • 5Pederson TR, Olsson AG, Faergeman O, et al. Lipoproteinchanges and reduction in the incidence of major coronaryheart disease events in the Scandinavian SimvastatinSurvival Study(4S)[J]. Circulation, 1998, 97(15):1453-1460.
  • 6Erkkil- AT1, N-rv-nen O, Lehto S, et al. Autoantibodiesagainst oxidized low-density lipoprotein and cardiolipin inpatients with coronary heart disease[J]. ArteriosclerThromb Vasc Biol, 2000, 20(1): 204-209.
  • 7Virella G, Thorpe SR, Alderson NL, et al. Autoimmuneresponse to advanced glycosylation end-products of humanlow density lipoprotein[J]. J Lipid Res, 2003, 44(3):487-493.
  • 8Soto Y, Conde H, Aroche R, et al. Autoantibodies tooxidized low density lipoprotein in relation with coronaryartery disease[J]. Hum Antibodies, 2009, 18(3): 109-117.
  • 9Tsimikas S, Brilakis ES, Lennon RJ, et al. Relationship ofIgG and IgM autoantibodies to oxidized low densitylipoprotein with coronary artery disease and cardiovascularevents[J]. J Lipid Res, 2007, 48(2): 425-433.
  • 10Su J, Georgiades A, Wu R, et al. Antibodies of IgMsubclass to phosphorylcholine and oxidized LDL areprotective factors for atherosclerosis in patients withhypertension[J]. Atherosclerosis, 2006, 188(1): 160-166.

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  • 1刘红涛,李广平,车京津,江明宏,曹雪滨.急性ST段抬高心肌梗死患者血清ox-LDL-AbIgM水平与冠脉病变程度及丙二醛、血脂的相关研究[J].实用老年医学,2013,27(6):480-482. 被引量:1
  • 2师军华,王东红.不同血液净化方式对终末期肾病患者血清抗氧化低密度脂蛋白抗体的影响[J].中国老年学杂志,2014,34(8):2107-2108. 被引量:12
  • 3LNBORG J, KELBeEK H, HELQVIST S, et al. The impact of distal embolization and distal protection on long-tem out- come in patients with ST elevation myocardial infarction ran- domized to primary percutaneous coronary intervention-re- suits from a randomized study[ J]. Eur Heart J Acute Card- iovasc Care, 2014,5 ( 5 ) : 89 - 93.
  • 4TANG B, ZHONG Z, SHEN HW, et al. Intermedin as a prog- nostic factor for major adverse cardiovascular events in pa- tients with ST-segment elevation acute myocardial infarction [ J ]. Peptides, 20t4,23 (7) :96-102.
  • 5WAHA S,EITEL I, DESCH S, et al. Prognosis after ST-ele- vation myocardial infarction: a study on cardiac magnetic resonance imaging versus clinical routine [ J ]. Trials, 2014, 15( 1 ) :249-252.
  • 6STONE SG, SERRAO GW1, MEHRAN R, et al, Incidence, Predictors, and Implications of Reinfarction After PrimaryPercutaneous Coronary Intervention in ST-Segment-Eleva- tion Myocardial Infarction :The Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial [ J ]. Circ Cardiovasc Interv, 2014,17 (6) : 82- 85.
  • 7LEURENT G, GARLANTIZEC R, AUFFRET V, et al. Gen- der differences in presentation, management and inhospital outcome in patients with ST-segment elevation myocardial infarction: Data from 5000 patients included in the ORBI prospective French regional registry [ J ] . Arch Cardiovasc Dis,2014,107 (5) :291-298.
  • 8PLANER D, MEHRAN R, OHMAN EM, et al. Prognosis of Patients With Non-ST-Segment-Elevation Myocardial Infarc- tion and Nonobstructive Coronary Artery Disease:Propensity- Matched Analysis From the Acute Catheterization and Ur- gent Intervention Triage Strategy Trial [ J ]. Circ Cardiovasc Interv,2014,7(3 ) :285-293.
  • 9王荣英,石汉文,田英平,郭宪立,马玉腾,苏建玲.缺血分级对急性心肌梗死患者心律失常的影响[J].中华急诊医学杂志,2012,21(2):141-145. 被引量:20
  • 10彭郑超.冠心病氧化型低密度脂蛋白自身抗体影响因素分析[J].浙江临床医学,2012,14(6):678-680. 被引量:3

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