他克莫司治疗肾小球疾病的研究进展

Progress on tacrolimus in treatment of glomerular disease

肾小球疾病是我国终末期肾病最主要原因。其发病机制不明,主要涉及体液免疫和细胞免疫过程。近年,他克莫司治疗免疫性肾小球疾病在临床上取得较好疗效。本文综述了他克莫司治疗肾小球疾病的机制和治疗进展。

Glomerular diseases are leading causes of end stage renal disease. The pathogenesis is prevalently immune mediated： humoral and cell-mediated immunity are involved, although the rationale for an etiological treatment is still unknown. In recent years, therapy of tacrolimus has a good curative effect in clinic. This article is aimed to review recent novel insights into mechanism and treatment of tacrolimus to guide practice in clinic.