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CD4^+CD25^+调节性T细胞与不同HBV感染状态的研究进展 被引量：3

CD4^+CD25^+ regulatory T cells and different states of HBV infection
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摘要 CD4+CD25+调节性T细胞是近年来发现的一类具有免疫负向调节功能的CD4+T细胞亚群.近年来研究表明CD4+CD25+调节性T细胞与不同乙型肝炎病毒(hepatitis B virus,HBV)感染状态的发生及发展密切相关.本文就CD4+CD25+调节性T细胞的分类、作用机制、免疫表型及其与不同HBV感染状态的研究进行综述. CD4＋CD25＋ regulatory T cells are a recently discovered subset of CD4＋ T cell population that mediates immune suppression. Recent studies suggested that regulatory T cells are closely associated with the prognosis of different states of HBV infection. Here we review the types, mechanisms of action and immunophenotypes of CD4＋CD25＋ regulatory T cells, as well as their relationship with different states of HBV infection.
作者 吕红 潘宗琴 胡世芸 邱隆敏
机构地区 遵义医学院附属医院感染科
出处 《世界华人消化杂志》 CAS 北大核心 2014年第10期1373-1377,共5页 World Chinese Journal of Digestology
基金 贵州省优秀科技教育人才省长专项基金资助项目 No.黔省专合字(2008)111号 贵州省社会发展公关基金资助项目 No.黔科合SY[2010]3049号~~
关键词 乙型肝炎病毒 T淋巴细胞 调节性 免疫 耐受 Hepatitis B virus T-lymphocytes Regulatory Immune tolerance
分类号 R512.62 [医药卫生—内科学]
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  • 1Hotehkiss RS, Coopersmith CM, McDunn JE, et al. The sepsis seesaw: tilting toward immunosuppression[J]. Nat Med, 2009, 15(5):496-497.
  • 2Frazier WJ, Hall MW. Immunoparalysis and adverse outcomes from critical illness[J]. Pediatr Clin North Am, 2008,55 (3) : 647-668.
  • 3Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure [J]. JAMA, 2011, 306(23):2594-2605.
  • 4Aziz M, Yang WL, Matsuo S, et al. Upregulation o- GRAIL Is Associated with Impaired CD4 T Cell Proliferation in Sepsis [J]. J Immunol, 2014, 192(5):2305-2314.
  • 5Venet F, Chung CS, Monneret G, et al. Regulatory T cell populations in sepsis and trauma[J]. J Leukoc Biol, 2008, 83 (3) :523-535.
  • 6Gouel-Cheron A, Allaouchiche B, Floccard B, et al. Early daily mHLA-DR monitoring predicts forthcoming sepsis in severe trauma patients[J]. Intensive Care Med, 2015, 41 (12) : 2229-2230.
  • 7Monneret G,Debard AL, Venet F, et al. Marked elevation of human circulating CD4+ CD25 + regulatory T cells in sepsis induced immunoparalysis[J]. Crit Care Med, 2003, 31 (7) : 2068-2071.
  • 8Cook DN, Hollingsworth JW Jr, Schwartz DA. Toll like receptors and the genetics of innate immunity[J]. Curr Opin Allergy Clin Immunol, 2003,3(6):523-529.
  • 9Amancha PK, Hong JJ, Rogers K, et al. In vivo blockade of the programmed cell death 1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit [J]. J Immunol, 2013, 191(12):6060-6070.
  • 10Lucas CL, Kuehn HS, Zhao F, et al. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p1103 result in T cellsenescence and./, human immunodeficiency[J]. Nat Immunol, 2014, 15 (1) : 88-97.

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世界华人消化杂志
2014年 第10期

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