乳腺癌组织中IGF-IR、SUSD3的表达及其临床意义

Expression of IGF-IR and SUSD3 in breast cancer and their clinical significance

目的探讨胰岛素样生长因子-I受体(IGF-IR)和SUSD3在乳腺癌组织中的表达情况,分析两者与临床病理特征的关系及其两者间的相关性。方法采用Max VisionTM免疫组化法检测100例乳腺癌组织和对应癌旁组织中IGF-IR、SUSD3的表达,并分析其与乳腺癌临床病理特征的关系。结果 IGF-IR在乳腺癌和癌旁组织中的阳性表达率分别为86.0%和3.0%(P<0.05),SUSD3在乳腺癌和癌旁组织中的阳性表达率分别为78.0%和2.0%(P<0.05)。乳腺癌组织中IGF-IR和SUSD3的表达与ER水平和病理类型有关(P<0.05),而与年龄、HER-2表达、Ki-67表达和分期均无关(P>0.05)。IGF-IR和SUSD3在乳腺癌组织中的表达呈正相关(r=0.553,P<0.01)。结论 IGF-IR、SUSD3可能与乳腺癌的发生、发展有关,与ER联合检测对判断乳腺癌预后和指导术后辅助治疗有重要意义。

Objective To investigate the expression of insulin-like growth factor-I receptor （ IGF-IR） and sushi domain-con-taining protein 3 （ SUSD3） in breast cancer tissue, and analyze their relationship with clinical parameters and the correlation between the two proteins. Methods The expression of IGF-IR and SUSD3 in 100 cases of beast cancer tissues and the corresponding adjacent normal breast tissues after surgery was detected by immunohistochemical technique MaxVisionTM , and the relationship with clinical pathological features was further analyzed. Results The positive rate of IGF-IR protein was 86.0% in breast cancer tissues, higher than 3.0% in adjacent normal breast tissues（P＆lt;0.05）.The positive expression rate of SUSD3 protein was 78.0% in breast cancer tis-sues, higher than 2.0% in adjacent normal breast tissues（ P＆lt;0.05） . The expression of IGF-IR and SUSD3 was related to estrogen re-ceptor and pathological types （ P＆lt;0.05） , but not with age, stage, the expression of HER-2 and Ki-67（ P＆gt;0. 05） . The expression of IGF-IR and SUSD3 in breast cancer tissue was positively related （ r=0.553, P＆lt;0.01） . Conclusion The expression of IGF-IR and SUSD3 may be correlated to the occurrence and development of breast cancer. The combined detection of IGF-IR, SUSD3 and ER may play an important role in judging prognosis and guiding adjuvant therapy after surgery of breast cancer.