EPHX1 A415G基因多态性与胃肠道肿瘤易感性的Meta分析

A meta-analysis of association between EPHX1 A415G polymorphism and digestive tract cancer susceptibility

目的：探讨微粒体环氧化物水解酶（ EPHX1） A415G基因多态性与胃肠道肿瘤易感性的关系。方法计算机检索PubMed、EMBASE、CBM、维普、万方及中国知网数据库，检索时间截至2013年5月，收集关于EPHX1 A415G基因多态性与胃肠道肿瘤易感性的研究。由2名评价者按照纳入和排除标准独立选择文献、提取资料、评价质量。采用STATA 11.0软件进行Meta分析，计算合并OR值及其95％CI并行敏感性分析和发表偏倚的评估。结果最终纳入18篇文献，包括5852例胃肠道肿瘤患者和8710例对照人群。纳入的结果在GG vs． AA、GA vs． AA、GG/GA vs． AA和GG vs． GA/AA基因型的比较模型中均无异质性。各遗传模型Meta分析结果显示，EPHX1 A415G基因多态性与胃肠道肿瘤遗传易感性的关联性无统计学意义[GG vs． AA：OR＝1.063，95％CI：0.888～1.273；GA vs． AA： OR＝0.935，95％CI：0.867～1.009；GG/GA vs． AA： OR＝0.948，95％CI：0.882～1.020；GG vs． GA/AA：OR＝1.091，95％CI：0.913～1.304]。结论 EPHX1 A415G基因多态性与胃肠道肿瘤易感性之间无明显相关性。

Objective To explore the correlation between polymorphism of microsomal epoxide hydrolase 1（ EPHX1） A415G and susceptibility to gastrointestinal tumors. Methods All eligible case-control studies published up to May 2013 were searched out from PubMed, EMABSE, CBM, VIP, WanFang and CNKI databases. Two reviewers independently identified the literature, extracted data and assessed the quality of included studies according to inclusion and exclusion criteria. Meta-analysis was performed using STA-TA 11？0 software to analyze. Results A total of 18 studies comprising 5852 patients and 8710 controls were finally included. The in-cluded studies showed good homogeneity in the four genetic models of GG vs. AA, GA vs. AA,GG/GA vs. AA and GG vs. GA/AA. O-verall, there was no significant association between polymorphism of EPHX1 A415G and susceptibility to gastrointestinal tumors[GG vs. AA：OR=1？063, 95%CI：0？888-1？273;GA vs. AA： OR=0？935, 95%CI： 0？867-1？009;GG/GA vs. AA： OR=0？948, 95% CI：0？882-1？020;GG vs. GA/AA：OR=1？091, 95% CI：0？913-1？304] . Conclusion This meta-analysis suggest that there is no corre-lation between polymorphism of EPHX1 A415G and susceptibility to gastrointestinal tumors.