Gamma delta T细胞及其抗肿瘤研究的进展

Research advance in gamma delta T cells and its antitumor activity

Gamma delta（γδ） T细胞表达Vγ9Vδ2 T细胞受体，占外周血T淋巴细胞的2％～5％左右，主要分布于黏膜相关淋巴组织，是T细胞的亚群之一。其免疫作用介于固有免疫和适应性免疫之间，为主要组织相容性复合体（ MHC）非限制性细胞，具有一定的非特异性杀伤肿瘤细胞的作用，并且具有广泛的抗瘤谱。许多研究证实γδ T细胞参与了机体免疫防御系统的第一道防线，未来以γδ T细胞为基础的细胞免疫疗法，将会成为肿瘤免疫治疗的新战略。本文将对γδ T细胞的抗肿瘤作用机制及其临床应用作一综述。

Gamma delta（γδ） T cells are minor subset of T lymphocytes（ 2%-5% of peripheral blood T lymphocytes） that ex-press Vγ9Vδ2 T cell receptors, mainly distributed in the mucosa-associated lymphoid tissue, are non-restricted cells of major histocom-patibility complex（ MHC） , can kill various tumor cells. Many data demonstrate thatγδT cells are involved in the first line of immune defense system. In the future, adoptive γδ T cells-based cell immunotherapy will become a new strategy for cancer immunotherapy. In this review, we provide an overview of its anti-tumor mechanism and clinical application.