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出血合并血栓形成为表现的获得性维生素K依赖性凝血因子缺乏症1例 被引量：3

A case of acquired vitamin K-dependent coagulation-factor deficiencies manifested as bleeding and embolism
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摘要 毒药中毒引起的获得性维生素K1依赖性凝血因子缺乏症绝大多数以出血倾向为主要表现,罕见合并血栓形成者。现报告1例如下。 A woman of 46years old was admitted due to skin bleeding and right lower extremity pain.Measurements of blood coagulation factors showed the deficiency of FⅡ,FⅦ,FⅨ,FⅩ,protein S and protein C.Right fibula vein embolism was confirmed by color-Doppler ultrasound.Vitamin K and fresh frozen plasma was supplied, and low molecular heparin was added 3days later.Skin bleeding and right lower extremity pain released.The patient was diagnosed acquired vitamin K-dependent coagulation-factor deficiencies supposed secondary to superwarfarins poisoning.
作者 廖桂萍 尹晓林 王丽 孔祥敬 陈永升 张新华
机构地区 解放军第
出处 《临床血液学杂志》 CAS 2014年第3期432-433,共2页 Journal of Clinical Hematology
关键词 血栓形成 获得性维生素K依赖性凝血因子缺乏症 超级华法林 embolism acquired vitamin K-dependent coagulation-factor deficiencies superwarfarins
分类号 R554 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献8

  • 1RAUCH A E,WE1NINGER R,PASQUALE D,et al. Superwarfarin poisoning: a significant public health problem[J]. J Community Health, 1994,19 : 55 - 65.
  • 2张丹如,徐武秀,张凤飞.溴敌隆中毒并发下肢静脉血栓形成1例报道[J].海峡药学,2011,23(1):150-151. 被引量：1
  • 3FRANCO D, EVERETT G, MANOUCHERI M. I smell a rat:a case report and literature review of para- doxical thrombosis and hemorrhage in a patient with brodifacoum toxicity [J]. Blood Coagul Fibrinolysis, 2013,24:202-204.
  • 4KONKLE B. Bleeding and thromhosis[M]//ETRH B,KASPER D L,STONE R M,et al. Harrison's inter- nal medicine. 17ed. New York: McGraw-Hill, 2008: 363-369.
  • 5DE PAULA E V, MONTALVAO S A, MADUREI- RAP R, et al. Simultaneous bleeding and thrombosis in superwarfarin poisoning[J]. Thromb Res, 2009, 123:637-639.
  • 6LAPOSATA M,VAN COTT E M,LEV M H. Case records of the Massachusetts General Hospital. Case 1-2007. A 40-year-old woman with epistaxis, he- matemesis,and altered mental status[J].N Engl J Med,2007,356: 174-182.
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二级参考文献7

  • 1刘明娟,施兵,叶丽萍,刘丽辉,金建刚,陈虎.以血尿为首发表现的溴敌隆中毒五例报告并文献复习[J].中国全科医学,2009,12(12):1109-1110. 被引量：9
  • 2董天义,阎丙申.三种新抗凝血剂毒饵防制家栖鼠实验室效果评价[J].医学动物防制,2004,20(6):333-337. 被引量：24
  • 3Michael Laposata,Elizabeth M.Van Cott,Michael H Lev,Case 1-2007.A 40-year-old woman with epistaxis,hematemesis,and altered mental status[J].N Eng1J Med,2007,356:174-182.
  • 4Michael Laposata,Elizabeth M.Van Cott,Michael H Lev.Case 1-2007.A 40-year-old woman with epistaxis,hematemesis,and altered mental status[J].N Eng1J Med,2007.356:174-182.
  • 5Erich Vinicius De Paula,Silmara Aparecida Lima Montalvao,Paulo Roberto Madureira,et al.Simultaneous bleeding and thrombosis in superwarfarin poisoning[J].Thrombosis Research.2009,123:637-639.
  • 6F.Papin,F.Clarot,C.Vicomte,et al.Lethal paradoxical cerebral vein thrombosis due to suspicious anticoagulant rodenticide intoxication with chlorophacinone[J].Forensic Sci Int,2007,166:85-90.
  • 7T.Lovejoy,A.Jacobson,S.Jacob.Clinical challenges of management of a coumarin rodenticide(brodifacoum)toxicity vs.warfarin toxicity:case report[J].J Thromb Thrombolysis,2008,25:113.

同被引文献37

  • 1Centorino MB, Sanchez DL, Catalano G,et al. The use of broma-diolone to potentiate self-mutilatory bleeding: a case report [J].Psychosomatics, 2012,53(5):489-493.
  • 2Waien SA, Hayes D Jr, Leonardo JM. Severe coagulopathy as aconsequence of smoking crack cocaine laced with rodenticide[J].N Engl J Med, 2001,345(9):700-701.
  • 3de Paula EV, Montalvao SA, Madureira PR, et al. Simultaneousbleeding and thrombosis in superwarfarin poisoning [J].Thromb Res,2009,.123(4): 637-639.
  • 4Papin F, Clarot F, Vicomte C, et al. Lethal paradoxical cerebralvein thrombosis due to suspicious anticoagulant rodenticideintoxication with chlorophacinone [J]. Forensic Sci Int, 2007,166(2-3): 85-90.
  • 5Laposata M, Van Cott EM, Lev MH. Case records of the Massa-chusetts General Hospital. Case 1-2007. A 40-year-old womanwith epistaxis, hematemesis, and altered mental status [J]. NEngl J Med, 2007,356(2); 174-182.
  • 6Franco D, Everett G, Manoucheri M. I smell a rat: a case reportand literature review of paradoxical thrombosis and hemorrhagein a patient with brodifacoum toxicity [J]. Blood Coagul Fibrino-lysis, 2013,24(2):202-204.
  • 7吴杰,单小鸥.溴敌隆中毒并发下肢血栓形成一例[J].中华儿科杂志,2010,48(7):550-551. 被引量：3
  • 8张丽娟,张义平.抗凝血杀鼠药中毒导致出血12例的临床分析[J].中国实用医刊,2011,38(19):69-70. 被引量：6
  • 9程锁明,王航宇,李国玉,朱芸,赵文斌,王金辉.中药白僵蚕的研究进展[J].农垦医学,2012,34(5):443-448. 被引量：28
  • 10王蕾,郭新红,江明,曲建华,段显琳,王新有.毒鼠药中毒致凝血异常19例临床分析[J].新疆医科大学学报,2013,36(7):962-964. 被引量：8

引证文献3

二级引证文献15

临床血液学杂志
2014年 第3期

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